Department of Ultrasound, The Second Hospital of Shandong University, Jinan, China.
Medical Image Center, The Second Hospital of Shandong University, Jinan, China.
Medicine (Baltimore). 2023 Aug 4;102(31):e34437. doi: 10.1097/MD.0000000000034437.
We investigated the risk factors of nonalcoholic fatty liver disease (NAFLD) in healthy women. This is a cross-sectional study. Healthy women who underwent physical examination were enrolled. Their basic information and medical history [including age, height, weight, body mass index (BMI)], abdominal ultrasound results, and, serological indexes [including white blood cells, platelet count, fasting blood glucose, triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDLC), uric acid (UA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamyl transpeptidase] were collected. Univariate and multivariate regression analysis was carried out to screen the risk factors of NAFLD. ALT/AST ratio, and BMI were significantly independent risk factors for the occurrence and severity of NAFLD. In addition, TG/HDLC ratio, and UA level also had significant independent correlation with NAFLD. ALT/AST ratio, BMI, TG/HDLC ratio, and UA are independent risk factors for the occurrence and severity of NAFLD. It is suggested that obesity, hyperlipidemia, hyperuricemia and high transaminase value are closely related to NAFLD. People with such conditions should pay more attention to early screening of NAFLD to avoid disease aggravation and the occurrence and development of other complications. In clinical practice, ALT/AST, BMI, TG/HDLC, and UA level should be closely monitored, so as to facilitate the follow-up management of the disease.
我们研究了健康女性非酒精性脂肪性肝病（NAFLD）的危险因素。这是一项横断面研究。我们招募了接受体检的健康女性。收集了她们的基本信息和病史[包括年龄、身高、体重、体重指数（BMI）]、腹部超声结果和血清学指标[包括白细胞、血小板计数、空腹血糖、甘油三酯（TG）、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇（HDLC）、尿酸（UA）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和谷氨酰转肽酶]。采用单因素和多因素回归分析筛选 NAFLD 的危险因素。ALT/AST 比值和 BMI 是 NAFLD 发生和严重程度的显著独立危险因素。此外，TG/HDLC 比值和 UA 水平与 NAFLD 也有显著的独立相关性。ALT/AST 比值、BMI、TG/HDLC 比值和 UA 是 NAFLD 发生和严重程度的独立危险因素。提示肥胖、血脂异常、高尿酸血症和高转氨酶值与 NAFLD 密切相关。有此类情况的人群应更加注意早期筛查 NAFLD，以避免病情加重和其他并发症的发生发展。在临床实践中，应密切监测 ALT/AST、BMI、TG/HDLC 和 UA 水平，以利于疾病的随访管理。
