Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Mov Disord. 2023 Nov;38(11):2121-2125. doi: 10.1002/mds.29573. Epub 2023 Aug 6.
Multiple system atrophy with parkinsonism (MSA-P) is a progressive condition with no effective treatment.
The aim of this study was to describe the safety and efficacy of deep brain stimulation (DBS) of globus pallidus pars interna and externa in a cohort of patients with MSA-P.
Six patients were included. Changes in Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III), Parkinson's Disease Questionnaire (PDQ-39) scores, and levodopa equivalent daily dose were compared before and after DBS. Electrode localization and volume tissue activation were calculated.
DBS surgery did not result in any major adverse events or intraoperative complications. Overall, no differences in MDS-UPDRS III scores were demonstrated (55.2 ± 17.6 preoperatively compared with 67.3 ± 19.2 at 1 year after surgery), although transient improvement in mobility and dyskinesia was reported in some subjects.
Globus pallidus pars interna and externa DBS for patients with MSA-P did not result in major complications, although it did not provide significant clinical benefit as measured by MDS-UPDRS III. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
多系统萎缩伴帕金森病（MSA-P）是一种进行性疾病，目前尚无有效治疗方法。
本研究旨在描述苍白球 intern 和 extern 深部脑刺激（DBS）在 MSA-P 患者中的安全性和疗效。
纳入 6 名患者。比较 DBS 前后运动障碍学会统一帕金森病评定量表第三部分（MDS-UPDRS III）、帕金森病问卷（PDQ-39）评分和左旋多巴等效日剂量的变化。计算电极定位和组织激活体积。
DBS 手术未导致任何重大不良事件或术中并发症。总体而言，MDS-UPDRS III 评分无差异（术前 55.2±17.6 分，术后 1 年 67.3±19.2 分），尽管一些患者报告运动和运动障碍有短暂改善。
苍白球 intern 和 extern 深部脑刺激治疗 MSA-P 患者未导致重大并发症，但如 MDS-UPDRS III 所示，并未提供显著的临床获益。© 2023 作者。运动障碍由 Wiley Periodicals LLC 代表国际帕金森病和运动障碍协会出版。
