Department of Medical Microbiology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey; Department of Medical Microbiology, Faculty of Medicine, İstanbul Aydın University, İstanbul, Turkey.
Department of Medical Microbiology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.
J Mycol Med. 2023 Nov;33(4):101416. doi: 10.1016/j.mycmed.2023.101416. Epub 2023 Aug 4.
Lomentospora prolificans is an opportunistic pathogen that can cause invasive lomentosporiosis in immunocompromised patients. Patients with hematological malignancies and those who have undergone stem cell or solid organ transplantations are in the highest risk group. In addition to the limitations and delays in diagnostic possibilities, L. prolificans has a high mortality due to its resistance to all available antifungal drugs. In a patient diagnosed with aplastic anemia, we described the first case of L. prolificans in Türkiye. L. prolificans was identified in the blood culture, and despite the initiation of antifungal treatments, the fungemia resulted in mortality on the 7th day of intensive care hospitalization. This case highlights the importance of early recognition and prompt initiation of appropriate antifungal therapy to improve the outcome of patients with rare mold infections.
繁茂枝孢霉是一种机会致病菌，可使免疫功能低下的患者发生侵袭性繁茂枝孢霉病。患有血液系统恶性肿瘤和接受过干细胞或实体器官移植的患者属于高危人群。除了诊断可能性的局限性和延迟之外，由于对所有可用抗真菌药物的耐药性，繁茂枝孢霉的死亡率很高。在诊断为再生障碍性贫血的患者中，我们在土耳其描述了首例繁茂枝孢霉病例。在血液培养物中发现了繁茂枝孢霉，尽管开始了抗真菌治疗，但真菌血症导致患者在重症监护住院的第 7 天死亡。该病例强调了早期识别和及时启动适当的抗真菌治疗以改善罕见霉菌感染患者预后的重要性。
