Sunni S, Bishop S P, Kent S P, Geer J C
Arch Pathol Lab Med. 1986 May;110(5):375-81.
The mechanism of heart failure in patients with diabetic cardiomyopathy is not clear. Previous studies suggested that vascular lesions specific for diabetes mellitus were present and that the lesions could be the basis for impaired cardiac function. We have investigated the histologic and histochemical characteristics of intramyocardial vessels (20 to 500 microns) in a group of diabetics using comparable groups of patients with hypertension, patients with hypertension and diabetes mellitus, and, as controls, patients with neither hypertension nor diabetes mellitus. Analysis of multiple blocks taken from the 42 study patients disclosed no lesions specific for diabetes mellitus or hypertension. The discrepancy between our findings and earlier reports is probably due to a lack of controls and the use of non-perfusion-fixed material in the earlier studies.
糖尿病性心肌病患者心力衰竭的机制尚不清楚。先前的研究表明，存在糖尿病特有的血管病变，这些病变可能是心脏功能受损的基础。我们使用高血压患者组、高血压合并糖尿病患者组以及既无高血压也无糖尿病的患者组作为对照，研究了一组糖尿病患者心肌内血管（20至500微米）的组织学和组织化学特征。对42名研究患者的多个组织块进行分析后发现，没有糖尿病或高血压特有的病变。我们的研究结果与早期报告之间的差异可能是由于早期研究缺乏对照以及使用了非灌注固定材料。
