2019-2020 年阳光充足的泰国维生素 D 现状更新。

Update on vitamin D status in sunshine-abundant Thailand, 2019-2020.

机构信息

Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Department of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Nutrition. 2023 Dec;116:112161. doi: 10.1016/j.nut.2023.112161. Epub 2023 Jul 11.

DOI:10.1016/j.nut.2023.112161

Abstract

OBJECTIVE

The prevalence of vitamin D deficiency worldwide remains unknown. In the Thai 4th National Health Examination Survey (2008-2009) cohort, ∼45% and 7% of the adult population had serum 25-hydroxyvitamin-D [25(OH)D] levels below the threshold of 75 and 50 nmol/L, respectively. Vitamin D has been a hot topic in the scientific community. The aim of this study was to uncover the current situation regarding vitamin D status in Thailand.

METHODS

Participants were 4098 adults ages 10 to 96 y, randomly selected from the Thai 6th National Health Examination Survey (2019-2020) cohort. Serum 25(OH)D levels were measured by liquid chromatography/tandem mass spectrometry. Data were expressed as mean ± SE and adjusted odds ratio (95% CI).

RESULTS

Mean vitamin D status based on serum 25(OH)D was 88.2 nmol/L and differed by age, sex, residency, and religion. The prevalence of serum 25(OH)D <75 and <50 nmol/L were 31% and 4%, respectively. The prevalence of vitamin D deficiency was lower in individuals who lived in the northeastern part of Thailand or were male. The risk for vitamin D deficiency was lower than that in 2009. In multiple linear regression analysis, female sex, younger age, urbanization, a higher body mass index, Muslim religion, and living in Bangkok or the central region of Thailand were independently associated with lower serum 25(OH)D levels.

CONCLUSIONS

The vitamin D status in the Thai population has improved over the past 10 y. This improvement may reflect an increased awareness related to adequate vitamin D status.

摘要

目的

全球范围内维生素 D 缺乏的流行情况尚不清楚。在泰国第四次全国健康体检调查（2008-2009 年）队列中，约有 45%和 7%的成年人血清 25-羟维生素 D [25（OH）D]水平分别低于 75 和 50nmol/L 的阈值。维生素 D 一直是科学界的热门话题。本研究旨在揭示泰国目前的维生素 D 状况。

方法

从泰国第六次全国健康体检调查（2019-2020 年）队列中随机抽取 4098 名 10-96 岁的成年人作为研究对象。采用液相色谱/串联质谱法检测血清 25（OH）D 水平。数据以均数±标准差和调整后的比值比（95%可信区间）表示。

结果

根据血清 25（OH）D 水平，维生素 D 状态的平均值为 88.2nmol/L，且因年龄、性别、居住地点和宗教信仰而异。血清 25（OH）D<75 和<50nmol/L 的发生率分别为 31%和 4%。维生素 D 缺乏症的发生率在居住在泰国东北部或男性中的人群中较低。与 2009 年相比，维生素 D 缺乏症的风险较低。在多元线性回归分析中，女性、年龄较小、城市化、较高的体质指数、穆斯林宗教信仰以及居住在曼谷或泰国中部地区与血清 25（OH）D 水平较低独立相关。