Department of Psychiatry, McGill University, Montreal, QC, Canada.
Department of Psychiatry, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Neurosci Biobehav Rev. 2023 Oct;153:105350. doi: 10.1016/j.neubiorev.2023.105350. Epub 2023 Aug 5.
In numerous brain structures, insulin signaling modulates the homeostatic processes, sensitivity to reward pathways, executive function, memory, and cognition. Through human studies and animal models, mounting evidence implicates central insulin signaling in the metabolic, physiological, and psychological consequences of early life adversity. In this review, we describe the consequences of early life adversity in the brain where insulin signaling is a key factor and how insulin may moderate the effects of adversity on psychiatric and cardio-metabolic health outcomes. Further understanding of how early life adversity and insulin signaling impact specific brain regions and mental and physical health outcomes will assist in prevention, diagnosis, and potential intervention following early life adversity.
在众多脑结构中，胰岛素信号调节着体内平衡过程、对奖励途径的敏感性、执行功能、记忆和认知。通过人体研究和动物模型，越来越多的证据表明中枢胰岛素信号参与了早期生活逆境对代谢、生理和心理的影响。在这篇综述中，我们描述了早期生活逆境对大脑的影响，其中胰岛素信号是一个关键因素，以及胰岛素如何调节逆境对精神和心脏代谢健康结果的影响。进一步了解早期生活逆境和胰岛素信号如何影响特定的大脑区域以及精神和身体健康结果，将有助于在早期生活逆境后进行预防、诊断和潜在干预。
