CD4 T 细胞有助于髓系细胞介导杀伤免疫逃逸肿瘤。
CD4 T cells help myeloid-mediated killing of immune-evasive tumors.
机构信息
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Trends Cancer. 2023 Oct;9(10):777-779. doi: 10.1016/j.trecan.2023.07.013. Epub 2023 Aug 5.
In a recent study published in Nature, Kruse et al. demonstrated an indirect tumor-killing mechanism orchestrated by a small number of CD4 effector T cells. These CD4 T cells can reprogram myeloid cells not just into IFNγ-induced antigen-presenting cells but also into iNOS-expressing tumoricidal effectors that can eradicate immune-evasive tumors.
在最近发表在《自然》杂志上的一项研究中，克吕泽等人展示了一种由少数 CD4 效应 T 细胞协调的间接肿瘤杀伤机制。这些 CD4 T 细胞不仅可以将髓样细胞重新编程为 IFNγ 诱导的抗原呈递细胞，还可以编程为表达 iNOS 的肿瘤杀伤效应器，从而根除免疫逃避肿瘤。
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