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衰老间充质干细胞中 Hippo 通路的激活导致老年小鼠肝脏炎症失调。

Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice.

机构信息

The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Stem Cells and Medical Biomaterials of Jiangsu Province, Medical College of Soochow University, Soochow University, Suzhou, 215000, China.

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.

出版信息

Adv Sci (Weinh). 2023 Sep;10(27):e2300424. doi: 10.1002/advs.202300424. Epub 2023 Aug 6.

DOI:10.1002/advs.202300424
PMID:37544916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10520691/
Abstract

Aging is always accompanied by chronic diseases which probably attribute to long-term chronic inflammation in the aging body. Whereas, the mechanism of chronic inflammation in aging body is still obscure. Mesenchymal stem cells (MSCs) are capable of local chemotaxis to sites of inflammation and play a powerful role in immune regulation. Whether degeneration of MSCs in the aging body is associated with unbalanced inflammation is still not clear. In this study, immunosuppressive properties of aged MSCs are found to be repressed. The impaired immunosuppressive function of aged MSCs is associated with lower expression of the Hippo effector Yes-associated protein 1 (YAP1) and its target gene signal transducer and activator of transcription 1 (STAT1). YAP1 regulates the transcription of STAT1 through binding with its promoter. In conclusion, a novel YAP1/STAT1 axis maintaining immunosuppressive function of MSCs is revealed and impairment of this signal pathway in aged MSCs probably resulted in higher inflammation in aged mice liver.

摘要

衰老是伴随着慢性疾病的，这可能归因于衰老机体的长期慢性炎症。然而，衰老机体中慢性炎症的机制仍不清楚。间充质干细胞（MSCs）能够向炎症部位趋化，并在免疫调节中发挥强大作用。衰老机体中 MSCs 的退化是否与炎症失衡有关尚不清楚。在这项研究中，发现衰老 MSCs 的免疫抑制特性受到抑制。衰老 MSCs 免疫抑制功能受损与 Hippo 效应物 Yes 相关蛋白 1（YAP1）及其靶基因信号转导和转录激活因子 1（STAT1）的表达降低有关。YAP1 通过与其启动子结合来调节 STAT1 的转录。总之，揭示了一个维持 MSCs 免疫抑制功能的新型 YAP1/STAT1 轴，而衰老 MSCs 中该信号通路的损害可能导致老年小鼠肝脏中炎症反应升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/0be11b178942/ADVS-10-2300424-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/4c68129ff43b/ADVS-10-2300424-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/2332d94981f1/ADVS-10-2300424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/156a972575f9/ADVS-10-2300424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/fecf1f3aac7e/ADVS-10-2300424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/0be11b178942/ADVS-10-2300424-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/4c68129ff43b/ADVS-10-2300424-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/5e225eb69275/ADVS-10-2300424-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/861ddfb85c12/ADVS-10-2300424-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/e112b4d7c0a4/ADVS-10-2300424-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/2332d94981f1/ADVS-10-2300424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/156a972575f9/ADVS-10-2300424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/fecf1f3aac7e/ADVS-10-2300424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eb0/10520691/0be11b178942/ADVS-10-2300424-g008.jpg

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2
Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions.小分子 LATS 激酶抑制剂在 3D 培养条件下阻断 Hippo 信号通路并促进细胞生长。
J Biol Chem. 2022 Apr;298(4):101779. doi: 10.1016/j.jbc.2022.101779. Epub 2022 Feb 26.
3
Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells.
Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide.
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Nutrients. 2024 Jul 20;16(14):2354. doi: 10.3390/nu16142354.
单细胞转录组分析揭示间充质干细胞的细胞异质性。
Genomics Proteomics Bioinformatics. 2022 Feb;20(1):70-86. doi: 10.1016/j.gpb.2022.01.005. Epub 2022 Feb 3.
4
Characterization and differentiation potential of mesenchymal stem cells isolated from multiple canine adipose tissue sources.从多种犬脂肪组织来源分离的间充质干细胞的鉴定和分化潜能。
BMC Vet Res. 2021 Dec 18;17(1):388. doi: 10.1186/s12917-021-03100-8.
5
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Int Immunopharmacol. 2022 Jan;102:108380. doi: 10.1016/j.intimp.2021.108380. Epub 2021 Nov 27.
6
Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice.单细胞测序揭示老年小鼠肿瘤内免疫细胞的抗肿瘤特征。
J Immunother Cancer. 2021 Oct;9(10). doi: 10.1136/jitc-2021-002809.
7
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.瘦素受体阳性间充质干细胞中的蛋白磷酸酶2A通过去磷酸化Runx2促进胚胎期和出生后软骨内成骨。
Commun Biol. 2021 Jun 2;4(1):658. doi: 10.1038/s42003-021-02175-1.
8
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