Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.
Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan, Iran.
J Mater Chem B. 2023 Aug 24;11(33):8056-8068. doi: 10.1039/d3tb01278f.
Bacterial infection is one of the main challenges of wound healing. It imposes financial and healthcare costs. The emergence of antibiotic-resistant bacteria has increased concerns about this challenge, and made finding alternative solutions a crucial aim. We created a new, antibacterial, multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound-healing applications. We fabricated a chitosan (CT)-based hydrogel containing tannic acid (TA), Fe, and MnO nanosheets (CT-TA-Fe-MnO) a simple method and characterized it. The antibacterial features (resulting from the production of reactive oxygen species within bacterial cells) and healing ability ( anti-inflammatory and hemostatic features) of the hydrogel were confirmed . results revealed the effectiveness of the CT-TA-Fe-MnO hydrogel in decreasing the hemostatic time, improving anti-inflammatory effects, and promoting wound healing during 14 days by enhancing the deposition and maturation of collagen fibers without affecting the vital organs. The fabricated CT-TA-Fe-MnO hydrogel could be a promising candidate with antibacterial and anti-inflammatory activities suitable for wound-healing applications.
细菌感染是伤口愈合的主要挑战之一。它会带来经济和医疗保健方面的成本。抗生素耐药菌的出现增加了人们对此挑战的担忧，使得寻找替代解决方案成为一个关键目标。我们开发了一种具有协同化学动力学和光热特性的新型抗菌多功能水凝胶，用于伤口愈合应用。我们采用一种简单的方法制备了一种包含单宁酸（TA）、Fe 和 MnO 纳米片的壳聚糖（CT）基水凝胶（CT-TA-Fe-MnO），并对其进行了表征。水凝胶的抗菌特性（源于细菌细胞内活性氧的产生）和愈合能力（抗炎和止血特性）得到了证实。结果表明，CT-TA-Fe-MnO 水凝胶可通过促进胶原蛋白纤维的沉积和成熟，在 14 天内降低止血时间、提高抗炎效果并促进伤口愈合，而不会影响重要器官。所制备的 CT-TA-Fe-MnO 水凝胶具有抗菌和抗炎活性，有望成为一种适用于伤口愈合应用的候选材料。
