Department of Radiology, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Neurology, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Acta Radiol. 2023 Sep;64(9):2590-2593. doi: 10.1177/02841851231185350. Epub 2023 Aug 6.
Transcranial direct current stimulation (tDCS) can potentially enhance brain function and cognition in healthy individuals as well as in patients with cognitive impairment. However, neural correlates of repeated tDCS remain relatively unexplored in a healthy population.
To assess the effects of repeated tDCS on regional cerebral blood flow (rCBF) in healthy volunteers in a pilot investigation.
Five healthy adults received bifrontal tDCS to the dorsolateral prefrontal cortex (F3-F4 montage, 1 mA intensity, 30 minutes/session, five sessions/week) over four weeks. All participants underwent brain single-photon emission computed tomography (SPECT) scans at baseline and one week after the last tDCS session. Changes in rCBF were examined using Statistical Parametric Mapping.
Resting rCBF was significantly improved in the right superior frontal gyrus at the follow-up ( < 0.001). Adverse events were not reported and the stimulation was well-tolerated.
Repeated tDCS may be effective for enhancing brain function in healthy participants. Larger sham-controlled studies should be performed to confirm our preliminary findings.
经颅直流电刺激（tDCS）可潜在增强健康个体以及认知障碍患者的大脑功能和认知能力。然而，在健康人群中，重复 tDCS 的神经相关因素仍相对未知。
在一项初步研究中评估重复 tDCS 对健康志愿者局部脑血流（rCBF）的影响。
五名健康成年人接受双侧额顶叶 tDCS 刺激（F3-F4 导联，1mA 强度，30 分钟/次，每周 5 次），持续四周。所有参与者在基线和最后一次 tDCS 治疗后一周都接受了脑单光子发射计算机断层扫描（SPECT）扫描。使用统计参数映射检查 rCBF 的变化。
在随访时，右侧额上回的静息 rCBF 显著改善（<0.001）。未报告不良事件，且刺激耐受性良好。
重复 tDCS 可能对增强健康参与者的大脑功能有效。应进行更大规模的假刺激对照研究来证实我们的初步发现。
