Liang Zhen, Yang Song, Wang Tao, Tang Ziren
Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Department of Emergency Medicine, Beijing Huai-Rou Hospital, Beijing 101400, China. Corresponding author: Tang Ziren, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023 Jul;35(7):773-776. doi: 10.3760/cma.j.cn121430-20230217-00095.
Targeted temperature management (TTM) has been partially applied in patients with restoration of spontaneous circulation (ROSC) after cardiac arrest (CA). In the 2020 American Heart Association (AHA) cardiopulmonary resuscitation (CPR) guidelines, TTM is used as advanced life support after ROSC for the treatment of patients with CPR. TTM has a protective effect on cardiac function after CA, but the specific mechanism of its protective effect on cardiac function remains unclear. In this paper, the basic experimental progress, clinical trial progress and development prospect of TTM on the protective mechanism of cardiac function after CA are reviewed.
目标温度管理(TTM)已部分应用于心脏骤停(CA)后恢复自主循环(ROSC)的患者。在2020年美国心脏协会(AHA)心肺复苏(CPR)指南中,TTM被用作ROSC后的高级生命支持,用于CPR患者的治疗。TTM对CA后的心脏功能具有保护作用,但其对心脏功能保护作用的具体机制仍不清楚。本文综述了TTM对CA后心脏功能保护机制的基础实验进展、临床试验进展及发展前景。