抗体对表面抗原的识别和细菌的清除受到荚膜多糖结构的影响。
surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure.
机构信息
Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
Division of Transboundary Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Kagoshima, Japan.
出版信息
Front Cell Infect Microbiol. 2023 Jul 21;13:1228496. doi: 10.3389/fcimb.2023.1228496. eCollection 2023.
is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survival in mice, antibody binding, and antibody-mediated bacterial killing. The CPS of serotypes 3, 4 and 14 allowed more antibody binding and bacterial elimination than the CPS of serotypes 2, 7 and 9. Results suggest that the different CPS structures of provide varying levels of protection by influencing antigen availability and elimination by the host immune system.
是一种囊封的细菌，可导致猪的严重疾病。在这里，我们通过在感染小鼠模型中使用血清型转换突变体，比较了不同血清型的荚膜多糖（CPS）的保护特性。CPS 结构影响细菌在小鼠中的存活、抗体结合和抗体介导的细菌杀伤。血清型 3、4 和 14 的 CPS 比血清型 2、7 和 9 的 CPS 允许更多的抗体结合和细菌消除。结果表明，通过影响宿主免疫系统的抗原可用性和消除，提供了不同水平的保护。
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