Petre Izabella, Sirbu Daniela Teodora, Petrita Ramona, Toma Andreea-Denisa, Peta Ema, Dimcevici-Poesina Florentina
Discipline of Obstetrics and Gynecology XII, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
University Clinic of Obstetrics and Gynecology, Emergency Clinic Hospital 'Pius Brinzeu', 300226 Timisoara, Romania.
Biomed Rep. 2023 Jul 7;19(2):54. doi: 10.3892/br.2023.1618. eCollection 2023 Aug.
Cervical lesions can be caused by pathogens, hormonal changes or by cervical injury. The recommended treatment in all cases is excision. Local re-epithelialization therapy should be initiated preoperatively and postoperatively. The present study assessed the post-market performance and tolerability of Cerviron ovules in the treatment and management of cervical lesions postoperatively. The study population included 345 participants aged 20-70 years with either a cervical lesion under treatment or with recent surgical removal of a cervical lesion. The degree of re-epithelialization of the cervical mucosa was improved in 73.17% of the patients evaluated during routine colposcopy exams and 92.73% of patients recorded no bleeding. When adding Cerviron either as monotherapy or in association with other antimicrobials in postoperative care of the cervical ectropion, improved postoperative outcomes such as reduced post-interventional bleeding and a superior quality of healing were observed. The study and its details are registered in under ID NCT05668806.
宫颈病变可由病原体、激素变化或宫颈损伤引起。所有病例的推荐治疗方法均为切除。术前和术后均应开始局部再上皮化治疗。本研究评估了Cerviron软胶囊在宫颈病变术后治疗和管理中的上市后性能及耐受性。研究人群包括345名年龄在20至70岁之间的参与者，他们要么正在接受宫颈病变治疗，要么近期接受了宫颈病变手术切除。在常规阴道镜检查中评估的患者中，73.17%的患者宫颈黏膜再上皮化程度得到改善，92.73%的患者无出血记录。在宫颈外翻术后护理中，单独使用Cerviron或与其他抗菌药物联合使用时，观察到术后结果有所改善，如介入后出血减少和愈合质量更高。该研究及其详细信息已在ID为NCT05668806下注册。
