Raleigh David, Mirchia Kanish, Choudhury Abrar, Joseph Tara, Birrueta Janeth, Phillips Joanna, Bhaduri Aparna, Crouch Elizabeth, Perry Arie
University of California San Francisco.
University of California, San Francisco.
Res Sq. 2023 Jul 26:rs.3.rs-3164953. doi: 10.21203/rs.3.rs-3164953/v1.
Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues.
脑膜孤立性纤维瘤（SFTs）是一种罕见的间充质肿瘤，与血行转移有关，其细胞状态和空间转录组结构尚不清楚。在这里，我们使用单细胞和空间RNA测序表明，SFTs由类似于脑血管发育和稳态的区域不同的基因表达程序组成。与其他中枢神经系统肿瘤相比，我们的结果揭示了SFT生物学的潜在通路，并为整合来自人类癌症和正常组织的单细胞和空间转录组数据提供了一个框架。
