成年雄性大鼠在产前接受烯丙雌醇治疗后胸腺糖皮质激素受体减少。
Reduced thymic glycocorticoid reception in adult male rats prenatally treated with allylestrenol.
作者信息
Inczefi-Gonda A, Csaba G, Dobozy O
出版信息
Acta Physiol Hung. 1986;67(1):27-9.
The first-generation male offsprings of female rats treated with allylestrenol on days 7 and 14 of the pregnancy showed in adulthood a considerable decrease in thymic dexamethasone binding. The diminution of binding capacity was due to an about 50% decrease in the number of the thymic dexamethasone receptors, since receptor affinity for the hormone was not altered by the applied treatment. This experimental observation has called attention to the possible hazards of allylestrenol treatment commonly applied to pregnant women for averting imminent abortions.
在孕期第7天和第14天用烯丙雌醇处理的雌性大鼠的第一代雄性后代在成年后胸腺地塞米松结合能力显著下降。结合能力的降低是由于胸腺地塞米松受体数量减少了约50%，因为所应用的处理并未改变受体对激素的亲和力。这一实验观察结果引起了人们对烯丙雌醇治疗常用于防止孕妇即将流产可能存在的危害的关注。
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