Karabélyos C, Szeberényi S, Csaba G
Department of Biology, Semmelweis University Medical School, Budapest, Hungary.
Acta Physiol Hung. 1994;82(1):15-22.
Treatment of pregnant rats with allyestrenol on the 15th and 19th days of pregnancy induced the activity of enzyme system of adult offspring in females while it did not influence it in males. The steroid anticoncipient treatment of adults decreased the activity of some enzymes of the PSMO. The adulthood anticoncipient steroid treatment of rats which encountered allylestrenol in their fetal age compared to the only anticoncipient steroid treated group produces an increased activity of the majority of the tested parameters both in females and males. The effect of the adulthood alcohol treatment was not influenced by the embryonic treatment with allylestrenol. Differences in the second generation are non-significant.
在妊娠第15天和第19天用烯丙雌醇治疗怀孕大鼠，可诱导成年雌性后代酶系统的活性，而对雄性后代则无影响。成年大鼠接受甾体避孕药治疗会降低PSMO某些酶的活性。与仅接受甾体避孕药治疗的组相比，在胎儿期接触过烯丙雌醇的成年大鼠接受甾体避孕药治疗后，雌性和雄性大鼠大多数测试参数的活性均增加。成年大鼠酒精治疗的效果不受烯丙雌醇胚胎期治疗的影响。第二代的差异不显著。
