Kosuta Iva, Ostojic Ana, Vujaklija Brajkovic Ana, Babel Jaksa, Simunov Bojana, Sremac Maja, Mrzljak Anna
Department of Intensive Care Medicine, University Hospital Centre Zagreb, Zagreb 10000, Croatia.
Department of Gastroenterology and Hepatology, Liver Transplant Center, University Hospital Centre Zagreb, Zagreb 10000, Croatia.
World J Hepatol. 2023 Jul 27;15(7):883-896. doi: 10.4254/wjh.v15.i7.883.
Liver diseases after kidney transplantation range from mild biochemical abnormalities to severe hepatitis or cirrhosis. The causes are diverse and mainly associated with hepatotropic viruses, drug toxicity and metabolic disorders. Over the past decade, the aetiology of liver disease in kidney recipients has changed significantly. These relates to the use of direct-acting antiviral agents against hepatitis C virus, the increasing availability of vaccination against hepatitis B and a better understanding of drug-induced hepatotoxicity. In addition, the emergence of the severe acute respiratory syndrome coronavirus 2 pandemic has brought new challenges to kidney recipients. This review aims to provide healthcare professionals with a comprehensive understanding of recent advances in the management of liver complications in kidney recipients and to enable them to make informed decisions regarding the risks and impact of liver disease in this population.
肾移植后的肝脏疾病范围从轻度生化异常到严重肝炎或肝硬化。病因多种多样，主要与嗜肝病毒、药物毒性和代谢紊乱有关。在过去十年中，肾移植受者肝脏疾病的病因发生了显著变化。这与抗丙型肝炎病毒直接作用抗病毒药物的使用、乙型肝炎疫苗接种的日益普及以及对药物性肝毒性的更好理解有关。此外，严重急性呼吸综合征冠状病毒2大流行的出现给肾移植受者带来了新的挑战。本综述旨在使医疗保健专业人员全面了解肾移植受者肝脏并发症管理的最新进展，并使他们能够就该人群肝脏疾病的风险和影响做出明智的决策。
