基因性心肌病中经活检证实的心肌炎症的多模态检测与靶向治疗：一项初步报告

Peretto Giovanni, De Luca Giacomo, Villatore Andrea, Di Resta Chiara, Sala Simone, Palmisano Anna, Vignale Davide, Campochiaro Corrado, Lazzeroni Davide, De Gaspari Monica, Rizzo Stefania, Busnardo Elena, Ferro Paola, Gianolli Luigi, Basso Cristina, Dagna Lorenzo, Esposito Antonio, Benedetti Sara, Della Bella Paolo

Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Myocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

JACC Basic Transl Sci. 2023 Jul 5;8(7):755-765. doi: 10.1016/j.jacbts.2023.02.018. eCollection 2023 Jul.

The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients.

作者发表了一篇临床报告，重点关注心肌炎与扩张型和致心律失常型遗传性心肌病之间的重叠情况。我们的队列由25名患者组成，他们在一个专门的多学科疾病单元接受了广泛的基线特征分析和前瞻性重新评估，中位随访时间为69个月。我们表明，使用多模态成像既可以区分特定基因型，又可以识别通过心内膜心肌活检证实的心肌炎症。此外，我们还表明，免疫调节治疗对大多数患者有益。