Yang Min, Gao Shuai, Yao Hao, He Xin, Fang Jiufei, Chen Yu, Liu Zhishun
Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Pediatr. 2023 Jul 21;11:1194651. doi: 10.3389/fped.2023.1194651. eCollection 2023.
This study aims to preliminarily evaluate the effect and safety of electroacupuncture (EA) in treating pediatric chronic urinary retention (CUR) following lumbosacral surgeries, with treatment duration evaluated.
This prospective case-series study was performed from August 5, 2017, to July 31, 2022. Pediatric patients diagnosed with CUR following lumbosacral surgeries were included and treated by EA for 2-16 weeks. Responders were defined as participants achieving a reduction of 50% or more in post void residuals (PVR) from baseline. Time-to-event analysis was applied to explore the association between EA treatment duration and response rate. Adverse event was recorded.
Totally 14 participants (mean [SD] age, 12 [4] years) completed EA treatment. Response rate was 71% (10/14) at the 12th week. 50% (7/14) of participants removed catheters at the 12th week, and none of them experienced re-catheterization in the 24-week follow-up. No serious adverse event was reported. Time-to-event analysis estimated that over 50% patients could respond to EA of more than 8 weeks. Subgroup analysis showed that participants with baseline PVR ≥300 ml and CUR duration ≥12 months experienced longer EA duration to reach the response rate of 50%, compared with those whose PVR <300 ml and CUR duration <12 months (median value: 12 weeks vs. 8 weeks, 12 weeks vs. 4 weeks, respectively).
EA could reduce PVR for pediatric patients suffering from CUR following lumbosacral surgeries, with long-term efficacy and safety. EA treatment of more than 8 weeks was reasonable. Further study of a larger sample and controlling is needed.
www.chictr.org.cn, identifier, ChiCTR1800020222.
本研究旨在初步评估电针（EA）治疗腰骶部手术后小儿慢性尿潴留（CUR）的疗效和安全性，并对治疗时间进行评估。
本前瞻性病例系列研究于2017年8月5日至2022年7月31日进行。纳入腰骶部手术后诊断为CUR的小儿患者，并接受EA治疗2至16周。反应者定义为与基线相比，排尿后残余尿量（PVR）减少50%或更多的参与者。采用事件发生时间分析来探讨EA治疗时间与反应率之间的关联。记录不良事件。
共有14名参与者（平均[标准差]年龄，12[4]岁）完成了EA治疗。第12周时反应率为71%（10/14）。50%（7/14）的参与者在第12周拔除了导尿管，且在24周的随访中均未再次插管。未报告严重不良事件。事件发生时间分析估计，超过50%的患者对超过8周的EA治疗有反应。亚组分析显示，与基线PVR<300 ml且CUR病程<12个月的参与者相比，基线PVR≥300 ml且CUR病程≥12个月的参与者达到50%反应率所需的EA治疗时间更长（中位数：分别为12周对8周，12周对4周）。
EA可降低腰骶部手术后患有CUR的小儿患者的PVR，具有长期疗效和安全性。8周以上的EA治疗是合理的。需要进一步进行更大样本量和对照的研究。
