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[治疗成人急性非淋巴细胞白血病的一种新药及当前策略]

[A new drug and current strategy in the treatment of acute non-lymphocytic leukemia in adults].

作者信息

Ogawa M

出版信息

Gan To Kagaku Ryoho. 1986 May;13(5):1829-36.

PMID:3754711
Abstract

Among new drugs being studied currently, AMSA and mitoxantrone have shown significant usefulness against acute non-lymphocytic leukemia in adults. Remission induction therapy consisting of daunomycin and cytosine arabinoside has been commonly selected as the first line of treatment and the complete remission rate obtained has exceeded 70%. Postremission therapy consolidation has been judged to be necessary while the clinical roles of maintenance and intensification remain to be clarified and appear to still require an investigational approach.

摘要

在目前正在研究的新药中,胺苯吖啶和米托蒽醌已显示出对成人急性非淋巴细胞白血病有显著疗效。由柔红霉素和阿糖胞苷组成的缓解诱导疗法通常被选为一线治疗方法,所获得的完全缓解率已超过70%。缓解后治疗巩固被认为是必要的,而维持和强化的临床作用仍有待阐明,似乎仍需要采用研究性方法。

相似文献

1
[A new drug and current strategy in the treatment of acute non-lymphocytic leukemia in adults].[治疗成人急性非淋巴细胞白血病的一种新药及当前策略]
Gan To Kagaku Ryoho. 1986 May;13(5):1829-36.
2
Amsacrine alone or in combination with 5-azacytidine and etoposide in refractory or relapsed acute non lymphoblastic leukemia (ANLL).安吖啶单独或与5-氮杂胞苷及依托泊苷联合用于难治性或复发性急性非淋巴细胞白血病(ANLL)。
Haematologica. 1985 Jan-Feb;70(1):39-43.
3
[Phase II trial of mitoxantrone in patients with relapsed and refractory acute leukemia].米托蒽醌治疗复发难治性急性白血病的II期试验
Gan To Kagaku Ryoho. 1985 Jul;12(7):1453-7.
4
[Phase II study of mitoxantrone in patients with acute leukemia].米托蒽醌治疗急性白血病患者的II期研究
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5
Mitoxantrone and cytarabine induction, high-dose cytarabine, and etoposide intensification for pediatric patients with relapsed or refractory acute myeloid leukemia: Children's Cancer Group Study 2951.米托蒽醌与阿糖胞苷诱导、大剂量阿糖胞苷以及依托泊苷强化治疗复发或难治性急性髓系白血病儿童患者:儿童癌症研究组2951研究
J Clin Oncol. 2003 Aug 1;21(15):2940-7. doi: 10.1200/JCO.2003.06.128.
6
A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML 97 Study.一项针对成人急性髓系白血病患者的随机缓解后比较研究:标准剂量巩固治疗四个疗程且不进行维持治疗与标准剂量巩固治疗三个疗程并进行维持治疗的对比——日本成人白血病研究组AML 97研究
Cancer. 2005 Dec 15;104(12):2726-34. doi: 10.1002/cncr.21493.
7
Acridinyl anisidide (m-AMSA) therapy in 11 patients with refractory acute leukemia.吖啶基茴香胺(m-AMSA)对11例难治性急性白血病患者的治疗。
Isr J Med Sci. 1984 Feb;20(2):118-22.
8
[Clinical activity of m-Amsa and the combination of m-Amsa with cytosine arabinoside].[米托蒽醌的临床活性以及米托蒽醌与阿糖胞苷联合用药的临床活性]
Nouv Presse Med. 1982 Oct 9;11(39):2911-4.
9
[Treatment of acute myeloid leukemia with amsacrine and high-dose cytosine arabinoside: a phase II trial].用安吖啶和大剂量阿糖胞苷治疗急性髓细胞白血病:一项II期试验
Bull Cancer. 1985;72(1):37-41.
10
New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.治疗急慢性白血病的新药,重点介绍胺苯吖啶。
Anticancer Res. 1991 Mar-Apr;11(2):705-11.