Chen Yurong, Wang Luyao, Guo Fucheng, Dai Xiangpeng, Zhang Xiaoling
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education First Hospital of Jilin University Changchun China.
National-Local Joint Engineering Laboratory of Animal Models for Human Disease First Hospital of Jilin University Changchun China.
MedComm (2020). 2023 Aug 2;4(4):e331. doi: 10.1002/mco2.331. eCollection 2023 Aug.
After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal-to-zygotic transition (MZT). MZT involves two major events that are maternal components degradation and zygotic genome activation. The epigenetic reprogramming plays crucial roles in regulating the process of MZT and supervising the normal development of early development of embryos. In recent years, benefited from the rapid development of low-input epigenome profiling technologies, new epigenetic modifications are found to be reprogrammed dramatically and may play different roles during MZT whose dysregulation will cause an abnormal development of embryos even abortion at various stages. In this review, we summarized and discussed the important novel findings on epigenetic reprogramming and the underlying molecular mechanisms regulating MZT in mammalian embryos. Our work provided comprehensive and detailed references for the in deep understanding of epigenetic regulatory network in this key biological process and also shed light on the critical roles for epigenetic reprogramming on embryonic failure during artificial reproductive technology and nature fertilization.
受精后，精子与卵母细胞融合形成受精卵，这是新生命的开始。随后，在胚胎发生早期，从卵母细胞向胚胎的转变过程中，胚胎发育受到精确的监测和调控，这一过程被称为母源-合子转变（MZT）。MZT涉及两个主要事件，即母源成分的降解和合子基因组的激活。表观遗传重编程在调节MZT过程和监督胚胎早期发育的正常进程中起着关键作用。近年来，受益于低投入表观基因组分析技术的快速发展，人们发现新的表观遗传修饰会发生显著的重编程，并且在MZT过程中可能发挥不同的作用，其失调会导致胚胎发育异常甚至在各个阶段流产。在这篇综述中，我们总结并讨论了关于表观遗传重编程以及调控哺乳动物胚胎MZT的潜在分子机制的重要新发现。我们的工作为深入理解这一关键生物学过程中的表观遗传调控网络提供了全面而详细的参考，也揭示了表观遗传重编程在辅助生殖技术和自然受精过程中对胚胎发育失败的关键作用。
