Misumi Yoshitsugu, Nonaka Kouichi, Kishino Maiko
Department of Digestive Endoscopy, Tokyo Women's Medical University Hospital, 8-1, Kawada-chou, Shinjuku-ku, Tokyo 162-8666, Japan.
Case Rep Gastrointest Med. 2023 Jul 26;2023:5620348. doi: 10.1155/2023/5620348. eCollection 2023.
PuraStat® (3D Matrix, Tokyo, Japan) is a novel, self-assembling peptide hemostatic hydrogel that can be used endoscopically. Hemostasis can be physically obtained by covering bleeding points; however, there are no reports of how long PuraStat remains in the upper gastrointestinal tract. Herein, we report a case wherein esophagogastroduodenoscopy (EGD) was performed 2 hours after PuraStat application. A 73-year-old man underwent EGD for evaluation of lesions in the posterior wall of the stomach. A biopsy was then performed on the gastric lesions; however, massive bleeding occurred. A hemostatic clip was used to stop bleeding but failed; primary hemostasis was obtained by applying PuraStat. EGD performed 2 hours later to determine whether the patient could be discharged revealed that the white-turning PuraStat gel remained firmly in the applied area, confirming complete hemostasis. PuraStat is a hemostatic agent capable of physical hemostasis that reliably remains in the stomach even after a few hours of use and, thus, may replace some conventional hemostasis methods.
PuraStat®（3D Matrix，日本东京）是一种新型的、可自组装的肽类止血水凝胶，可用于内镜检查。通过覆盖出血点可实现物理止血；然而，尚无关于PuraStat在上消化道中停留时间的报道。在此，我们报告一例在应用PuraStat后2小时进行食管胃十二指肠镜检查（EGD）的病例。一名73岁男性因评估胃后壁病变接受了EGD检查。随后对胃部病变进行了活检；然而，出现了大量出血。使用止血夹止血但失败了；通过应用PuraStat实现了初步止血。2小时后进行EGD以确定患者是否可以出院，结果显示变白的PuraStat凝胶仍牢固地留在应用部位，证实止血完全。PuraStat是一种能够实现物理止血的止血剂，即使使用数小时后也能可靠地留在胃中，因此可能会取代一些传统的止血方法。
