登革病毒诱导的巨噬细胞毒素在体内的产生。
Production of dengue virus-induced macrophage cytotoxin in vivo.
作者信息
Gulati L, Chaturvedi U C, Mathur A
出版信息
Br J Exp Pathol. 1986 Apr;67(2):269-77.
We have observed that dengue virus-induced cytotoxic factor (CF) induces peritoneal and splenic macrophages in vitro to produce a cytotoxin (CF2). This study demonstrates also production of CF2 in vivo in DV-infected mice and following inoculation with CF. The cell-type responsible for CF2 production in vivo is the macrophage (M phi) as M phi-depleted mice failed to produce CF2. CF2 activity could not be observed in the serum or peritoneal fluid though it is produced in peritoneal M phi. Once stimulated, CF2 is present for 4 h in M phi. M phi can be restimulated to produce CF2 only after a refractory period of 48 h.
我们观察到登革病毒诱导的细胞毒性因子（CF）在体外可诱导腹膜和脾巨噬细胞产生一种细胞毒素（CF2）。本研究还证明，在感染登革病毒的小鼠体内以及接种CF后，体内也会产生CF2。体内负责产生CF2的细胞类型是巨噬细胞（M phi），因为巨噬细胞耗竭的小鼠无法产生CF2。尽管CF2是在腹膜巨噬细胞中产生的，但在血清或腹膜液中未观察到CF2活性。一旦受到刺激，CF2在巨噬细胞中存在4小时。巨噬细胞只有在48小时的不应期后才能再次受到刺激产生CF2。
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