登革病毒诱导的细胞毒性因子可诱导巨噬细胞产生一种细胞毒素。
Dengue virus-induced cytotoxic factor induces macrophages to produce a cytotoxin.
作者信息
Gulati L, Chaturvedi U C, Mathur A
出版信息
Immunology. 1983 May;49(1):121-30.
In our earlier studies we have observed that T lymphocytes of dengue type 2 virus (DV)-infected mouse spleen produce a cytotoxic factor (CF). In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatography. CF2 is produced by an induction process and is present intracellularly as well as leaking out of the cells. CF2 kills most of the macrophages and some of the T cells, as observed with CF. It appears that CF2 is produced to amplify the effect of CF and/or for cooperative action with CF.
在我们早期的研究中，我们观察到登革2型病毒（DV）感染的小鼠脾脏中的T淋巴细胞会产生一种细胞毒性因子（CF）。在本研究中，已观察到CF可诱导小鼠脾脏和腹腔巨噬细胞产生一种细胞毒素（CF2），这已通过二乙氨基乙基纤维素色谱法得到证实。CF2是通过诱导过程产生的，既存在于细胞内，也会从细胞中泄漏出来。正如用CF观察到的那样，CF2可杀死大多数巨噬细胞和一些T细胞。似乎产生CF2是为了放大CF的作用和/或与CF协同作用。
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