登革病毒诱导的抑制信号的靶细胞研究。
Study of the target cell of the dengue virus-induced suppressor signal.
作者信息
Shukla M I, Chaturvedi U C
出版信息
Br J Exp Pathol. 1984 Apr;65(2):267-73.
Abstract
Dengue type 2 virus (DV) induces two generations of T suppressor cells (Ts1 and Ts2) in murine spleen. The Ts2 cells produce a soluble factor ( SF2 ) which suppresses DV-specific IgM antibody plaque-forming cells (PFC). In this study the target cell of SF2 was examined. The results show that SF2 requires a third generation of T cells (T3) in order to mediate suppression. The surface phenotype of this T3 cell is Ly 1+ and the suppression mediated is antigen specific.
摘要
登革2型病毒（DV）在小鼠脾脏中诱导产生两代T抑制细胞（Ts1和Ts2）。Ts2细胞产生一种可溶性因子（SF2），它能抑制DV特异性IgM抗体空斑形成细胞（PFC）。在本研究中，对SF2的靶细胞进行了检测。结果表明，SF2需要第三代T细胞（T3）来介导抑制作用。这种T3细胞的表面表型为Ly 1+，介导的抑制作用具有抗原特异性。
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