State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, P. R. China.
School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China.
Adv Mater. 2023 Nov;35(47):e2304005. doi: 10.1002/adma.202304005. Epub 2023 Oct 16.
Chronic wounds have become a significant threat to people's physical and mental health and have increased the burden of social medical care. Intelligent wound dressing (IWD) with wound condition monitoring and closed-loop on-demand drug therapy can shorten the healing process and alleviate patient suffering. However, single-function wound dressings cannot meet the current needs of chronic wound treatment. Here, a wearable IWD consisting of wound exudate management, sensor monitoring, closed-loop therapy, and flexible circuit modules is reported, which can achieve effective synergy between wound exudate management and on-demand wound therapy. The dressing is attached to the wound site, and the wound exudate is spontaneously pumped into the microfluidic channel for storage. Meanwhile, the IWD can detect the state of the wound through the temperature and humidity sensor, and use this as feedback to control the liquid metal (LM) heater through a smartphone, thereby realizing the on-demand drug release from the hydrogel. In a mouse model of infected wounds, IWD accelerates wound healing by reducing inflammatory responses, promoting angiogenesis and collagen deposition.
慢性伤口对人们的身心健康构成了重大威胁，并加重了社会医疗负担。具有伤口状况监测和闭环按需药物治疗功能的智能伤口敷料（IWD）可以缩短愈合过程，减轻患者的痛苦。然而，单一功能的伤口敷料无法满足当前慢性伤口治疗的需求。在这里，我们报告了一种由伤口渗出液管理、传感器监测、闭环治疗和柔性电路模块组成的可穿戴式 IWD，它可以实现伤口渗出液管理和按需伤口治疗之间的有效协同作用。该敷料贴在伤口部位，伤口渗出液会自发地被吸入微流道进行储存。同时，IWD 可以通过温度和湿度传感器检测伤口状态，并通过智能手机对液态金属（LM）加热器进行反馈控制，从而实现水凝胶的按需药物释放。在感染性伤口的小鼠模型中，IWD 通过减少炎症反应、促进血管生成和胶原蛋白沉积来加速伤口愈合。
