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Neuro Oncol. 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150.
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The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis.动脉自旋标记在成人胶质瘤分级中的价值：系统评价与荟萃分析。
Oncotarget. 2019 Feb 22;10(16):1589-1601. doi: 10.18632/oncotarget.26674.
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Change in quality of life in relation to returning to work after acquired brain injury: a population-based register study.获得性脑损伤后重返工作岗位对生活质量的影响：一项基于人群的登记研究。
Brain Inj. 2018;32(13-14):1731-1739. doi: 10.1080/02699052.2018.1517224. Epub 2018 Oct 8.
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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.全球、区域和国家癌症发病率、死亡率、生命损失年数、失能生存年数以及 32 种癌症组别的伤残调整生命年数，1990 年至 2015 年：全球疾病负担研究的系统分析。
JAMA Oncol. 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688.
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Global Neurosurgery: The Unmet Need.全球神经外科：未满足的需求。
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7
Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method.用动脉自旋标记法评估胶质肿瘤的灌注；与动态磁敏感对比法比较。
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8
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The role of dynamic susceptibility contrast-enhanced perfusion MR imaging in differentiating between infectious and neoplastic focal brain lesions: results from a cohort of 100 consecutive patients.动态磁敏感对比增强灌注磁共振成像在鉴别感染性和肿瘤性局灶性脑病变中的作用：来自 100 例连续患者队列的结果。
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尝试基于 ASL 的动脉化脑血容量作为胶质肿瘤分级的新型成像生物标志物。

Experimenting with ASL-based arterialized cerebral blood volume as a novel imaging biomarker in grading glial neoplasms.

机构信息

1Department of Imaging Sciences and Interventional Radiology, Sree Chita Institute of Medical Sciences and Technology, Trivandrum, Kerala, India.

Department of Research, Army Hospital Research and Referral, New Delhi, India.

出版信息

Neuroradiol J. 2023 Dec;36(6):728-735. doi: 10.1177/19714009231193163. Epub 2023 Aug 7.

DOI:10.1177/19714009231193163
PMID:37548164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10649543/
Abstract

BACKGROUND

Perfusion imaging is one of the methods used to grade glial neoplasms, and in this study we evaluated the role of ASL perfusion in grading brain glioma.

PURPOSE

The aim is to evaluate the role of arterialized cerebral blood volume (aCBV) of multi-delay ASL perfusion for grading glial neoplasm.

MATERIALS AND METHODS

This study is a prospective observational study of 56 patients with glial neoplasms of the brain who underwent surgery, and only cases with positive diagnosis of glioma are included to evaluate the novel diagnostic parameter.

RESULTS

In the study, ASL-derived normalized aCBV (naCBV) and T2DSC-derived normalized CBV (nCBV) are showing very high correlation (Pearson's correlation coefficient value of 0.94) in grading glial neoplasms. naCBV and nCBF are also showing very high correlation (Pearson's correlation coefficient value of 0.876). The study also provides cutoff values for differentiating LGG from HGG for normalized aCBV(naCBV) of ASL, normalized CBV (nCBV), and normalized nCBF derived from T2 DCS as 1.12, 1.254, and 1.31, respectively. ASL-derived aCBV also shows better diagnostic accuracy than ASL-derived CBF.

CONCLUSION

This study is one of its kind to the best of our knowledge where multi-delay ASL perfusion-derived aCBV is used as a novel imaging biomarker for grading glial neoplasms, and it has shown high statistical correlation with T2* DSC-derived perfusion parameters.

摘要

背景

灌注成像是用于分级神经胶质瘤的方法之一，本研究评估动脉化脑血容量（aCBV）在脑胶质瘤分级中的作用。

目的

旨在评估多延迟动脉自旋标记（ASL）灌注的 aCBV 在分级神经胶质瘤中的作用。

材料与方法

这是一项对 56 例接受脑胶质瘤手术的患者进行的前瞻性观察性研究，仅纳入胶质瘤诊断明确的病例来评估新的诊断参数。

结果

研究中，ASL 衍生的标准化 aCBV（naCBV）和 T2* 扩散加权成像（DCS）衍生的标准化 CBV（nCBV）在分级神经胶质瘤方面具有非常高的相关性（Pearson 相关系数值为 0.94）。naCBV 和 nCBF 也具有非常高的相关性（Pearson 相关系数值为 0.876）。该研究还提供了用于区分低级别胶质瘤（LGG）和高级别胶质瘤（HGG）的 ASL 衍生的标准化 aCBV（naCBV）、T2* DCS 衍生的标准化 CBV（nCBV）和标准化 nCBF 的截断值，分别为 1.12、1.254 和 1.31。ASL 衍生的 aCBV 也显示出比 ASL 衍生的 CBF 更高的诊断准确性。

结论

本研究是目前所知的首例使用多延迟 ASL 灌注衍生的 aCBV 作为神经胶质瘤分级的新型影像学生物标志物的研究，其与 T2* DCS 衍生的灌注参数具有高度统计学相关性。