研究苹果皮提取物补充剂对调节高血脂女性人体葡萄糖代谢的营养保健品潜力。

Investigating the nutraceutical potential of apple peel extract supplementation for regulating the glucose metabolism in hyperlipidemic Female human subjects.

机构信息

BHU Budh Ghulam, Vehari, Pakistan.

BHU Meeray Shah Tehsil Sadiqabad, Rahim Yar Khan, Pakistan.

出版信息

Pak J Pharm Sci. 2023 Mar;36(2(Special)):625-629.

Abstract

Hyperglycemia is a condition often observed in diabetics, dyslipidemia and obese. It is a major factor behind the development of diabetes and the reasons can be genetics, environmental factors, dietary choices and obesity. Many medicinal plants have anti-diabetic potential. This study investigated the anti-hyperglycemic effect of apple peel extract. This study also investigated the chemical characterization of apple peel. Phytochemicals including total phenolics and flavonoids were determined. Encapsulated 350mg/day was given to treatment groups. Random blood sugar, fasting blood sugar and HbA1c of 45 diabetic female adults was measured on the 0-day and 45 day. Results showed that apple peel contained moisture (14.71±3.57)%, ash (17.82±2.13)%, nitrogen free extract (32.12±3.52)%, crude protein (6.89±0.83)%, crude fiber (19.17±0.21)% and crude fat (9.91±2.31)%. Findings showed that apple peel contains magnesium (6.61±1.088), calcium (8.17±0.32), zinc (14.08±1.21) and potassium (67.21±1.86). These findings were shown in mg in kg. Apple peel extract contained total phenolic content (TPC) of 8.14±1.07 and total phenolic content (TFC) of 4.89±1.81. Apple peel extract showed a significant reduction in all blood parameters of hyperglycemia. All results were significant at p<0.05.

摘要

高血糖是糖尿病患者常见的一种病症，同时还伴有血脂异常和肥胖。它是糖尿病发展的主要因素，其原因可能是遗传、环境因素、饮食选择和肥胖。许多药用植物具有降血糖的潜力。本研究调查了苹果皮提取物的降血糖作用。本研究还研究了苹果皮的化学特征。测定了包括总酚和类黄酮在内的植物化学物质。给予治疗组每天 350 毫克的包封。45 名患有糖尿病的成年女性在第 0 天和第 45 天测量随机血糖、空腹血糖和 HbA1c。结果表明，苹果皮含有水分（14.71±3.57）%、灰分（17.82±2.13）%、无氮提取物（32.12±3.52）%、粗蛋白（6.89±0.83）%、粗纤维（19.17±0.21）%和粗脂肪（9.91±2.31）%。结果表明，苹果皮含有镁（6.61±1.088）、钙（8.17±0.32）、锌（14.08±1.21）和钾（67.21±1.86）。这些发现以 mg/kg 表示。苹果皮提取物总酚含量（TPC）为 8.14±1.07，总酚含量（TFC）为 4.89±1.81。苹果皮提取物显著降低了所有高血糖血液参数。所有结果在 p<0.05 时均有显著差异。