BHU Budh Ghulam, Vehari, Pakistan.
BHU Meeray Shah Tehsil Sadiqabad, Rahim Yar Khan, Pakistan.
Pak J Pharm Sci. 2023 Mar;36(2(Special)):625-629.
Hyperglycemia is a condition often observed in diabetics, dyslipidemia and obese. It is a major factor behind the development of diabetes and the reasons can be genetics, environmental factors, dietary choices and obesity. Many medicinal plants have anti-diabetic potential. This study investigated the anti-hyperglycemic effect of apple peel extract. This study also investigated the chemical characterization of apple peel. Phytochemicals including total phenolics and flavonoids were determined. Encapsulated 350mg/day was given to treatment groups. Random blood sugar, fasting blood sugar and HbA1c of 45 diabetic female adults was measured on the 0-day and 45 day. Results showed that apple peel contained moisture (14.71±3.57)%, ash (17.82±2.13)%, nitrogen free extract (32.12±3.52)%, crude protein (6.89±0.83)%, crude fiber (19.17±0.21)% and crude fat (9.91±2.31)%. Findings showed that apple peel contains magnesium (6.61±1.088), calcium (8.17±0.32), zinc (14.08±1.21) and potassium (67.21±1.86). These findings were shown in mg in kg. Apple peel extract contained total phenolic content (TPC) of 8.14±1.07 and total phenolic content (TFC) of 4.89±1.81. Apple peel extract showed a significant reduction in all blood parameters of hyperglycemia. All results were significant at p<0.05.
高血糖是糖尿病患者常见的一种病症，同时还伴有血脂异常和肥胖。它是糖尿病发展的主要因素，其原因可能是遗传、环境因素、饮食选择和肥胖。许多药用植物具有降血糖的潜力。本研究调查了苹果皮提取物的降血糖作用。本研究还研究了苹果皮的化学特征。测定了包括总酚和类黄酮在内的植物化学物质。给予治疗组每天 350 毫克的包封。45 名患有糖尿病的成年女性在第 0 天和第 45 天测量随机血糖、空腹血糖和 HbA1c。结果表明，苹果皮含有水分（14.71±3.57）%、灰分（17.82±2.13）%、无氮提取物（32.12±3.52）%、粗蛋白（6.89±0.83）%、粗纤维（19.17±0.21）%和粗脂肪（9.91±2.31）%。结果表明，苹果皮含有镁（6.61±1.088）、钙（8.17±0.32）、锌（14.08±1.21）和钾（67.21±1.86）。这些发现以 mg/kg 表示。苹果皮提取物总酚含量（TPC）为 8.14±1.07，总酚含量（TFC）为 4.89±1.81。苹果皮提取物显著降低了所有高血糖血液参数。所有结果在 p<0.05 时均有显著差异。
