NHC介导的醇的光催化脱氧反应用于合成内炔——一种Csp-Csp偶联反应。

NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes a Csp-Csp coupling reaction.

作者信息

Ma Xueji, Wang Liujie, Meng Xiaoqing, Li Wenbo, Wang Qin, Gu Yuke, Qiu Lingna

机构信息

School of Pharmacy, Key Laboratory of Nano-carbon Modified Film Technology Engineering of Henan Province, Xinxiang University, Xinxiang 453000, P. R. China.

出版信息

Org Biomol Chem. 2023 Aug 23;21(33):6693-6696. doi: 10.1039/d3ob01066j.

DOI:10.1039/d3ob01066j

PMID:37548245

Abstract

NHC-mediated deoxygenation of alcohols under photocatalytic conditions is described. The process provides various alkyl radicals, which can react with 1-bromoalkyne Csp-Csp coupling to afford internal alkynes in moderate to good yields. The method offers a new and convenient approach to synthesize internal alkynes.

摘要

描述了在光催化条件下NHC介导的醇脱氧反应。该过程产生各种烷基自由基，这些自由基可与1-溴代炔烃发生Csp-Csp偶联反应，以中等至良好的产率得到内炔烃。该方法为合成内炔烃提供了一种新的便捷途径。