关于海蟹（Carcinus maenas）Y器官蜕皮激素生物合成的研究。

Studies on the biosynthesis of ecdysone by the Y-organs of Carcinus maenas.

作者信息

Lachaise F, Meister M F, Hétru C, Lafont R

出版信息

Mol Cell Endocrinol. 1986 May;45(2-3):253-61. doi: 10.1016/0303-7207(86)90155-3.

Abstract

High specific activity tritiated ecdysone precursor, 2,22,25-trideoxyecdysone, was incubated with Y-organs from intermoult and premoult shore crabs. Several metabolites were identified among which ecdysone and 25-deoxyecdysone. The concomitant production of these 2 molecules by Y-organs and their subsequent hydroxylation at C-20 by peripheral tissues, provide an explanation for the presence of both 20-hydroxyecdysone and ponasterone A (25-deoxy-20-hydroxyecdysone) in the circulating haemolymph of crabs.

摘要

将高比活度的氚化蜕皮激素前体2,22,25-三脱氧蜕皮激素与蜕皮间期和蜕皮前期滨蟹的Y器官一起孵育。鉴定出了几种代谢产物，其中包括蜕皮激素和25-脱氧蜕皮激素。Y器官同时产生这两种分子，随后它们在周围组织中于C-20位发生羟基化，这就解释了蟹类循环血淋巴中同时存在20-羟基蜕皮激素和泼那甾酮A（25-脱氧-20-羟基蜕皮激素）的原因。