Da Cunha Teresa, Vaziri Haleh
Department of Gastroenterology and Hepatology, University of Connecticut, Farmington, CT.
J Clin Gastroenterol. 2024 Jan 1;58(1):1-11. doi: 10.1097/MCG.0000000000001901.
Inflammatory bowel disease (IBD) increases the risk of dysplasia and colorectal cancer (CRC). Moreover, colitis-associated CRC is responsible for a disproportionate number of CRC-related mortality. For this reason, societies recommend screening and surveillance colonoscopy as the standard of care for patients with ulcerative colitis and Crohn's colitis. Nonetheless, interval cancer defined as CRC detected within the appropriate surveillance interval might still occur despite following guideline recommendations. Even though there is limited data on risk factors associated with interval CRC in IBD, patient and disease-associated factors and technical aspects of the surveillance might play a role. This review aims to provide information on the epidemiology of interval CRC in IBD, the factors that might be associated with its occurrence, and the challenges of CRC screening and dysplasia management in patients with IBD.
炎症性肠病（IBD）会增加发育异常和结直肠癌（CRC）的风险。此外，结肠炎相关的结直肠癌导致的CRC相关死亡率过高。因此，各学会推荐筛查和监测结肠镜检查作为溃疡性结肠炎和克罗恩氏结肠炎患者的标准治疗方法。尽管如此，即使遵循指南建议，在适当监测间隔内检测到的定义为CRC的间期癌仍可能发生。尽管关于IBD中间期CRC相关危险因素的数据有限，但患者和疾病相关因素以及监测的技术方面可能起一定作用。本综述旨在提供有关IBD中间期CRC的流行病学、可能与其发生相关的因素以及IBD患者CRC筛查和发育异常管理挑战的信息。
