Clin Nephrol. 2023 Oct;100(4):181-184. doi: 10.5414/CN111046.
Massive proteinuria and hypoalbuminemia are potential risk factors in thromboembolic complications. Venous thrombosis is a frequent complication of thromboembolism in patients with membranous glomerulonephritis, while arterial thrombosis is much less reported. A 35-year-old man presented with nephrotic syndrome and osteofascial compartment syndrome in the right lower limb due to arterial thrombosis. The biopsy findings were consistent with those of stage 2 membranous nephropathy. After immunotherapy (steroids and cyclosporine), the massive proteinuria, renal function, and serum albumin improved markedly. This is the first case of adult membranous glomerulonephritis with unilateral lower extremity arterial thrombosis diagnosed by renal biopsy and arteriography. It further confirms the high incidence of thromboembolic complications with membranous nephropathy.
大量蛋白尿和低白蛋白血症是血栓栓塞并发症的潜在危险因素。静脉血栓形成是膜性肾小球肾炎患者血栓栓塞的常见并发症，而动脉血栓形成则较少见。一名 35 岁男性因动脉血栓形成出现肾病综合征和右下肢骨筋膜间隔综合征。活检结果符合 2 期膜性肾病。免疫治疗（类固醇和环孢素）后，大量蛋白尿、肾功能和血清白蛋白明显改善。这是首例经肾活检和血管造影诊断的成人膜性肾小球肾炎伴单侧下肢动脉血栓形成的病例。它进一步证实了膜性肾病血栓栓塞并发症的高发生率。
