Burgess Helen J, Weber Kathleen M, Morack Ralph, Yohannes Tsion, Xing Jiaqian, Xue Xiaonan, Gustafson Deborah, Sharma Anjali, Daubert Elizabeth, Rogando Andrea C, French Audrey L
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Hektoen Institute of Medicine/CORE Center of Cook County Health, Chicago, Illinois, USA.
Brain Behav. 2023 Oct;13(10):e3206. doi: 10.1002/brb3.3206. Epub 2023 Aug 7.
Despite significant improvements in longevity and quality of life associated with antiretroviral therapy, individuals with HIV still suffer from a higher burden of sleep and circadian disruption and inflammatory-based diseases than individuals without HIV. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti-inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV.
The aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35-70 years with HIV (n = 151) to a well-matched comparison group of women without HIV (n = 147). All women wore a wrist actigraphy monitor and completed daily diaries documenting sleep timing and use of medications and drugs or alcohol for 10 days. Participants collected their overnight urine near the end of the monitoring period.
Melatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin. Higher body mass index predicted lower levels of melatonin, and lower levels of melatonin were associated with lower sleep efficiency as assessed with wrist actigraphy.
These data lay the foundation for exploration of the longitudinal consequences of endogenous melatonin levels for inflammatory-based diseases in aging women with and without HIV. Future studies should consider the use of supplemental melatonin to improve sleep in women with lower levels of melatonin.
尽管抗逆转录病毒疗法在延长寿命和提高生活质量方面取得了显著进展，但与未感染艾滋病毒的个体相比，感染艾滋病毒的个体仍承受着更高的睡眠和昼夜节律紊乱以及炎症性疾病负担。褪黑素是一种在睡眠和昼夜节律调节中起作用且具有抗炎特性的激素，但艾滋病毒感染者夜间尿褪黑素代谢物的浓度尚未见报道。
本研究的目的是比较35至70岁感染艾滋病毒的女性（n = 151）与匹配良好的未感染艾滋病毒的女性对照组（n = 147）夜间尿褪黑素代谢物水平。所有女性均佩戴腕部活动记录仪，并在10天内完成每日日记，记录睡眠时间以及药物、毒品或酒精的使用情况。参与者在监测期接近尾声时收集夜间尿液。
感染艾滋病毒和未感染艾滋病毒的女性之间褪黑素水平无差异，但超过40%的女性褪黑素水平较低。较高的体重指数预示着较低的褪黑素水平，且较低的褪黑素水平与腕部活动记录仪评估的较低睡眠效率相关。
这些数据为探索内源性褪黑素水平对感染和未感染艾滋病毒的老年女性炎症性疾病的纵向影响奠定了基础。未来的研究应考虑使用补充褪黑素的方法来改善褪黑素水平较低女性的睡眠。
