Ahmadi-Motamayel Fatemeh, Vaziri-Amjad Samaneh, Goodarzi Mohammad Taghi, Samie Lida, Poorolajal Jalal
Dental Research Center and Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan. Iran.
Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan. Iran.
Rev Recent Clin Trials. 2017;12(3):168-173. doi: 10.2174/1574887112666170725132528.
Human immunodeficiency virus (HIV) affects lymphocytes, resulting in acquired immunodeficiency syndrome. Oxidative stress may play an important role in HIV pathogenesis. Melatonin has antioxidant, antiinflammatory and immunomodulatory effects.
The aim of this study was to evaluate salivary melatonin levels in HIV-positive patients and a healthy control group.
Forty-nine HIV-positive and 49 healthy subjects were included in this study. Patients' drug consumption and clinical examination results were registered in questionnaires. Unstimulated whole saliva was collected in the morning. The melatonin levels were measured by melatonin ELISA kits. Statistical analyses were performed with STATA 12, using t-test and chi-squared test.
Salivary melatonin levels were significantly lower in the case group in comparison with the healthy control group (P=0.001). Age was significantly higher in the case group. Chi-squared test showed no statistically significant difference between the case and control groups in smoking (P=0.591) and addiction (P=0.204) but gender differences were observed (P=0.001).
Salivary melatonin level as an antioxidant was lower in HIV-positive patients. Further studies are necessary to understand the exact role of melatonin in HIV-positive patients and its therapeutic effects.
人类免疫缺陷病毒（HIV）会影响淋巴细胞，导致获得性免疫缺陷综合征。氧化应激可能在HIV发病机制中起重要作用。褪黑素具有抗氧化、抗炎和免疫调节作用。
本研究旨在评估HIV阳性患者和健康对照组唾液中褪黑素水平。
本研究纳入49例HIV阳性患者和49名健康受试者。患者的用药情况和临床检查结果记录在问卷中。早晨采集未刺激的全唾液。采用褪黑素酶联免疫吸附测定试剂盒测量褪黑素水平。使用STATA 12进行统计分析，采用t检验和卡方检验。
病例组唾液褪黑素水平显著低于健康对照组（P = 0.001）。病例组年龄显著更高。卡方检验显示病例组和对照组在吸烟（P = 0.591）和成瘾（P = 0.204）方面无统计学显著差异，但观察到性别差异（P = 0.001）。
HIV阳性患者唾液中作为抗氧化剂的褪黑素水平较低。有必要进一步研究以了解褪黑素在HIV阳性患者中的确切作用及其治疗效果。
