Genç Çiğdem Çetin, Genç Celal, Yenigürbüz Fatma Demir
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çanakkale Onsekiz Mart University, Cumhuriyet District Sahilyolu Street, No:5, Kepez, Çanakkale, Turkey.
Department of Orthodontics, Faculty of Dentistry, Çanakkale Onsekiz Mart University, Cumhuriyet District Sahilyolu Street, No:5, Kepez, Çanakkale, Turkey.
Clin Oral Investig. 2023 Oct;27(10):5793-5803. doi: 10.1007/s00784-023-05191-z. Epub 2023 Aug 7.
The present study aims to compare β-thalassemia major patients and healthy individuals in terms of anthropometric characteristics and changes in craniofacial profile.
Craniofacial anthropometric measurements were performed on a total of 422 subjects (199 β-thalassemia major patients and 223 healthy individuals) by using a millimetric caliper and tape measure on 19 anthropometric parameters (8 horizontal, 10 vertical, and 1 head circumference) in cranial, facial, nasal, orolabial, and orbital zones.
The difference between the orbital, nasal, and orolabial zone parameters of healthy subjects and β-thalassemia major patients was found to be statistically significant (p < 0.05). There was no statistically significant difference between the groups in terms of head circumference in the cranial zone and total facial height in facial zone (n-gn) values (p˃0.05). In intragroup comparison between females and males with β-thalassemia, statistically significant differences were found in forehead width (ft-ft), forehead height (tr-gl), right eye width (R ex-ex), and upper lip height (sn-stm) (p < 0.05).
Understanding the craniofacial profile changes in β-thalassemia major patients and increasing our knowledge about the relationship between the course and severity of disease and the level of these changes would contribute to the advancements in diagnoses to be made in facial and jaw zones of these patients and in the treatment plans.
We believe that the analysis and results of the craniofacial anthropometric data obtained in the study will contribute to the diagnosis and treatment processes of patients with β-thalassemia major in areas of expertise such as craniofacial surgery, orthodontics, and hemato-oncology.
本研究旨在比较重型β地中海贫血患者与健康个体在人体测量特征及颅面部轮廓变化方面的差异。
对总共422名受试者（199名重型β地中海贫血患者和223名健康个体）进行颅面部人体测量，使用毫米卡尺和卷尺测量颅部、面部、鼻部、口唇部及眶部区域的19项人体测量参数（8项水平参数、10项垂直参数和1项头围）。
发现健康受试者与重型β地中海贫血患者在眶部、鼻部及口唇部区域参数上的差异具有统计学意义（p < 0.05）。两组在颅部区域的头围及面部区域的总面高（n - gn）值方面无统计学显著差异（p > 0.05）。在重型β地中海贫血患者的性别组内比较中，在前额宽度（ft - ft）、前额高度（tr - gl）、右眼宽度（R ex - ex）及上唇高度（sn - stm）方面发现有统计学显著差异（p < 0.05）。
了解重型β地中海贫血患者的颅面部轮廓变化，并增加我们对疾病进程和严重程度与这些变化程度之间关系的认识，将有助于推进对这些患者面部和颌部区域的诊断及治疗方案的制定。
我们认为本研究中获得的颅面部人体测量数据的分析及结果将有助于重型β地中海贫血患者在颅面外科、正畸学及血液肿瘤学等专业领域的诊断和治疗过程。
