Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, 650504, PR China; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, PR China.
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, PR China.
Phytochemistry. 2023 Oct;214:113817. doi: 10.1016/j.phytochem.2023.113817. Epub 2023 Aug 6.
Nine pairs of undescribed enantiomers, (±)-styraxoids A-I (1-9), were isolated from the resin of Styrax tonkinensis, and their structures were assigned by spectroscopic and computational methods. Compounds (±)-1 are a pair of degraded lignans, and the remaining compounds (±)-(2-9) are phenylpropanoid skeletons. Compounds (±)-8 and (±)-9 feature a 1,3-dioxolane moiety. The biological evaluation showed that both enantiomers of 1 could inhibit LPS-induced INOS and COX-2 in RAW264.7 cells in a dose-dependent manner.
从越南安息香树脂中分离得到了 9 对未描述的对映异构体（±）-styraxoids A-I（1-9），并通过光谱和计算方法确定了它们的结构。化合物（±）-1 是一对降解的木质素，其余化合物（±）-（2-9）是苯丙素骨架。化合物（±）-8 和（±）-9 具有 1,3-二氧戊环部分。生物评价表明，1 的两种对映异构体均可剂量依赖性地抑制 LPS 诱导的 RAW264.7 细胞中 INOS 和 COX-2 的表达。
