Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering and Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Department of Pharmacy, School of Medicine, Jianghan University, Wuhan, 430056, China.
J Nat Med. 2020 Sep;74(4):819-824. doi: 10.1007/s11418-020-01437-2. Epub 2020 Jul 21.
Two new phenylpropanoids, named stytonkinol A (1) and stytonkinol B (2), have been isolated from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI-MS. Two isolated compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by Cell Counting Kit-8 (CCK-8) test in vitro. The cytotoxic effectiveness observed against Hela, and MCF-7 cell lines of compound 1 were superior or similar to the positive control cisplatin (IC values of 40.95 and 47.36 μM), with IC values of 26.75 and 45.16 μM, respectively, while it showed moderate cytotoxic activities against the HepG-2 and PC-3 cell lines. Compound 2 showed moderate cytotoxic activities on cells MCF-7 with IC values of 57.1 μM.
从越南安息香树脂中分离得到两个新的苯丙素类化合物，分别命名为stytonkinol A（1）和 stytonkinol B（2）。通过光谱分析，包括 1D 和 2D NMR 和 HR-ESI-MS，确定了它们的结构。采用细胞计数试剂盒（CCK-8）法体外检测了两种分离化合物对五种肿瘤细胞系（HepG-2、A549、Hela、MCF-7 和 PC-3）的细胞毒性。化合物 1 对 Hela 和 MCF-7 细胞系的细胞毒性作用优于或与阳性对照顺铂（IC 值分别为 40.95 和 47.36 μM）相当，IC 值分别为 26.75 和 45.16 μM，而对 HepG-2 和 PC-3 细胞系表现出中等细胞毒性作用。化合物 2 对 MCF-7 细胞表现出中等细胞毒性，IC 值为 57.1 μM。
