印度那瓦西孟血液培养确认肠热病病例的回顾性研究：2014-2018 年。
Retrospective Review of Blood Culture-Confirmed Cases of Enteric Fever in Navi Mumbai, India: 2014-2018.
机构信息
National Public Health Surveillance Project, World Health Organization-Country Office for India, New Delhi, India.
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
出版信息
Am J Trop Med Hyg. 2023 Aug 7;109(3):571-574. doi: 10.4269/ajtmh.23-0102. Print 2023 Sep 6.
India has one of the highest estimated burdens of enteric fever globally. Prior to the implementation of Typbar-TCV typhoid conjugate vaccine (TCV) in a public sector pediatric immunization campaign in Navi Mumbai, India, we conducted a retrospective review of blood culture-confirmed cases of typhoid and paratyphoid fevers to estimate the local burden of disease. This review included all blood cultures processed at a central microbiology laboratory, serving multiple hospitals, in Navi Mumbai (January 2014-May 2018) that tested positive for either Salmonella Typhi or Salmonella Paratyphi A. Of 40,670 blood cultures analyzed, 1,309 (3.2%) were positive for S. Typhi (1,201 [92%]) or S. Paratyphi A (108 [8%]). Culture positivity was highest in the last months of the dry season (April-June). Our findings indicate a substantial burden of enteric fever in Navi Mumbai and support the importance of TCV immunization campaigns and improved water, sanitation, and hygiene.
印度是全球估计肠热病负担最高的国家之一。在印度那瓦西孟邦开展的一项公共部门儿科免疫接种活动中引入 Typhbar-TCV 伤寒结合疫苗（TCV）之前，我们对血培养确诊的伤寒和副伤寒病例进行了回顾性审查，以估计当地疾病负担。该审查包括在那瓦西孟邦为多家医院服务的一个中央微生物学实验室处理的所有血培养物（2014 年 1 月至 2018 年 5 月），这些培养物检测出伤寒沙门氏菌或甲型副伤寒沙门氏菌阳性。在分析的 40670 个血培养物中，有 1309 个（3.2%）对 S. Typhi（1201 个[92%]）或 S. Paratyphi A（108 个[8%]）呈阳性。培养阳性率在旱季最后几个月（4 月至 6 月）最高。我们的研究结果表明那瓦西孟邦有大量的肠热病负担，支持 TCV 免疫接种活动以及改善水、卫生和卫生条件的重要性。
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