Reuter W, Sauer I, Herrmann W
Z Alternsforsch. 1986 Mar-Apr;41(2):91-4.
Lipid metabolic disorders are clinical relevant for the middle and old age. The presented paper shows that decreased HDL-cholesterol and increased triglycerides enlarge the value of pre-ageing. Therefore is a lipid lowering treatment a special problem of gerontology. We have treated 15 patients (age 56.7 +/- 7.8 years) with hypercholesterolemia and hypertriglyceridemia with the new developed lipids regulans X50 = 1-benzyl-3-(1-carboxy-1-methylethoxy)-4-methylpyrazol. There was a significant decreases of serumtriglycerides (47%) in all patients. Half of the patients showed a significant decreases of total cholesterol (32%). Biological age index and biological age were not influenced. To demonstrate an influence of biological age there are needed longterm treatments in patients with lipid metabolic disorders.
脂质代谢紊乱在中老年人群中具有临床相关性。本文表明，高密度脂蛋白胆固醇降低和甘油三酯升高会增大早衰的值。因此，降脂治疗是老年医学中的一个特殊问题。我们用新开发的脂质调节剂X50 = 1-苄基-3-(1-羧基-1-甲基乙氧基)-4-甲基吡唑治疗了15例高胆固醇血症和高甘油三酯血症患者（年龄56.7 +/- 7.8岁）。所有患者的血清甘油三酯均显著降低（47%）。一半的患者总胆固醇显著降低（32%）。生物学年龄指数和生物学年龄未受影响。为了证明对生物学年龄的影响，需要对脂质代谢紊乱患者进行长期治疗。
