National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Engineering Research Center of Animal Innovative Drugs and Safety Evaluation, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Engineering Research Center of Animal Innovative Drugs and Safety Evaluation, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Trends Microbiol. 2024 Feb;32(2):162-177. doi: 10.1016/j.tim.2023.07.010. Epub 2023 Aug 6.
Enterococci are ubiquitous members of the gut microbiota in human beings and animals and are among the most important nosocomial organisms. Due to their opportunistic pathogenicity, enterococci are referred to as pathobionts and play decisive roles in a diverse array of polymicrobial infections. Enterococci can promote the colonization, pathogenesis, and persistence of various pathogens, compromise the efficacy of drugs, and pose a severe threat to public health. Most current treatments tend to focus on the sole pathogenic bacteria, with insufficient attention to the driving role of enterococci. In this review, we summarize the characteristics of enterococci in infections, the factors facilitating their outgrowth, as well as the sites and types of enterococci-associated polymicrobial infections. We present an overview of the underlying mechanisms of enterococci-mediated pathogenesis in polymicrobial infections. Furthermore, we discuss alternative strategies and potential intervention approaches to restrict such infections, shedding light on the discovery and development of new therapies against polymicrobial infections.
肠球菌是人类和动物肠道微生物群中无处不在的成员，也是最重要的医院获得性生物体之一。由于其机会致病性，肠球菌被称为条件致病菌，在多种混合感染中发挥决定性作用。肠球菌可以促进各种病原体的定植、发病和持续存在，降低药物的疗效，并对公共健康构成严重威胁。目前大多数治疗方法往往侧重于单一的致病菌，而对肠球菌的驱动作用关注不足。在这篇综述中，我们总结了肠球菌在感染中的特征、促进其生长的因素，以及肠球菌相关混合感染的部位和类型。我们概述了肠球菌介导混合感染发病机制的潜在机制。此外，我们还讨论了限制此类感染的替代策略和潜在干预方法，为发现和开发针对混合感染的新疗法提供了思路。
