LY164846的体外抗菌活性测试，包括使用30微克纸片的纸片扩散药敏试验。

LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks.

作者信息

Jones R N, Baker C, Barry A L, Fuchs P C

出版信息

Antimicrob Agents Chemother. 1986 Mar;29(3):530-4. doi: 10.1128/AAC.29.3.530.

DOI:10.1128/AAC.29.3.530

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180430/

Abstract

A new oral cephalosporin, LY164846 (Eli Lilly & Co., Indianapolis, Ind.), was found to have a unique antimicrobial spectrum confined to methicillin-susceptible Staphylococcus spp., streptococci (except Enterococcus spp.), Haemophilus influenzae, Branhamella catarrhalis, and some anaerobes. Cephalothin in vitro tests (30-microgram disks or dilution) can represent LY164846 for laboratory testing if comparable interpretive breakpoints are applied to strains within the spectrum of LY164846. Organisms not inhibited by LY164846 (MICs greater than or equal to 32 micrograms/ml) were members of the family Enterobacteriaceae, Pseudomonas spp., Acinetobacter spp., enterococci, and some strains of Staphylococcus haemolyticus and of the Bacteroides fragilis group.

摘要

一种新型口服头孢菌素LY164846（礼来公司，印第安纳波利斯，印第安纳州）被发现具有独特的抗菌谱，仅限于对甲氧西林敏感的葡萄球菌属、链球菌（肠球菌属除外）、流感嗜血杆菌、卡他布兰汉菌以及一些厌氧菌。如果将可比的解释性断点应用于LY164846谱内的菌株，头孢噻吩体外试验（30微克纸片或稀释法）可用于实验室检测来代表LY164846。未被LY164846抑制的微生物（最低抑菌浓度大于或等于32微克/毫升）包括肠杆菌科、假单胞菌属、不动杆菌属、肠球菌以及一些溶血葡萄球菌菌株和脆弱拟杆菌群菌株。

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