Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
First Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Sci Rep. 2023 Aug 7;13(1):12758. doi: 10.1038/s41598-023-39938-1.
Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition with high mortality and a high permanent disability rate. In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. A single-center, retrospective observational study was conducted at Gifu University Hospital. Patients transported to the emergency room for aSAH and diagnosed with World Federation of Neurosurgical Societies (WFNS) grade III and IV aSAH between April 2004 and March 2021 were enrolled. A logistic regression model was constructed to evaluate the association of the CONUT score with a modified Rankin scale (mRS) ≥ 3 and delayed cerebral ischemia (DCI). 127 patients diagnosed with WFNS grade III and IV aSAH were analyzed. CONUT score was significantly associated with mRS ≥ 3 during hospitalization. The score obtained by subtracting the CONUT score at admission from the maximum CONUT score was significantly associated with mRS ≥ 3 at discharge. Moreover, the score obtained by subtracting the CONUT score at admission from the maximum CONUT score during the first 14 days was significantly associated with DCI within 14 days from admission. These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients.
颅内动脉瘤性蛛网膜下腔出血（aSAH）是一种死亡率高、永久性残疾率高的严重疾病。在本研究中，我们研究了 aSAH 患者住院期间的临床结局与控制营养状态（CONUT）评分之间的关系。这是一项在岐阜大学医院进行的单中心、回顾性观察性研究。纳入了 2004 年 4 月至 2021 年 3 月期间因 aSAH 被转运至急诊室且 WFNS 分级为 III 级和 IV 级的患者。构建了一个逻辑回归模型来评估 CONUT 评分与改良 Rankin 量表（mRS）≥3 和迟发性脑缺血（DCI）之间的关系。共分析了 127 例 WFNS 分级为 III 级和 IV 级的 aSAH 患者。CONUT 评分与住院期间 mRS≥3 显著相关。从入院时的 CONUT 评分减去最大 CONUT 评分所得到的分数与出院时的 mRS≥3 显著相关。此外，从入院第一天至第 14 天期间的 CONUT 评分减去最大 CONUT 评分所得到的分数与入院后 14 天内的 DCI 显著相关。这些发现表明，住院期间的 CONUT 评分可能是预测 aSAH 患者不良结局的有用的日常标志物。
