Shang Feng, Zhao Hao, Cheng Weitao, Qi Meng, Wang Ning, Qu Xin
Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China.
Front Surg. 2021 Oct 26;8:719226. doi: 10.3389/fsurg.2021.719226. eCollection 2021.
To determine the effect of the serum albumin level on admission in patients with spontaneous subarachnoid hemorrhage (SAH). A total of 229 patients with SAH were divided into control and hypoalbuminemia groups. The serum albumin levels were measured. The data, including age, gender, co-existing medical conditions, risk factors, Hunt-Hess (H-H) grade on admission, Glasgow coma score (GCS) on admission, complications during hospitalizations, length of hospital stay, length of intensive care unit (ICU) stay, in-hospital mortality, survival rate, outcome at discharge, and the 6-month follow-up outcome, were compared between the two groups. Older age, an increased number of patients who consumed an excess of alcohol, and a lower GCS on admission were findings in the hypoalbuminemia group compared to the control group ( < 0.001). The ratio of patients with H-H grade I on admission in the hypoalbuminemia group was decreased compared to the control group ( < 0.05). Patients with hypoalbuminemia were more likely to be intubated, and have pneumonia and cerebral vasospasm than patients with a normal albumin level on admission ( < 0.001). Furthermore, the length of hospital and ICU stays were longer in the hypoalbuminemia group than the control group ( < 0.001). Hypoalbuminemia on admission significantly increased poor outcomes at discharge ( < 0.001). The number of patients with severe disability was increased and the recovery rate was decreased with respect to in-hospital outcomes in the hypoalbuminemia group than the control group ( < 0.001). Hypoalbuminemia was shown to be associated with a poor prognosis in patients with SAH.
为确定血清白蛋白水平对自发性蛛网膜下腔出血(SAH)患者入院时的影响。总共229例SAH患者被分为对照组和低白蛋白血症组。测量血清白蛋白水平。比较两组之间的数据,包括年龄、性别、并存的内科疾病、危险因素、入院时的Hunt-Hess(H-H)分级、入院时的格拉斯哥昏迷评分(GCS)、住院期间的并发症、住院时间、重症监护病房(ICU)住院时间、院内死亡率、生存率、出院结局以及6个月随访结局。与对照组相比,低白蛋白血症组的患者年龄更大、饮酒过量的患者数量更多、入院时的GCS更低(P<0.001)。与对照组相比,低白蛋白血症组入院时H-H I级患者的比例降低(P<0.05)。与入院时白蛋白水平正常的患者相比,低白蛋白血症患者更有可能接受插管,并且发生肺炎和脑血管痉挛(P<0.001)。此外,低白蛋白血症组的住院时间和ICU住院时间比对照组更长(P<0.001)。入院时的低白蛋白血症显著增加出院时的不良结局(P<0.001)。与对照组相比,低白蛋白血症组院内结局中重度残疾患者数量增加且恢复率降低(P<0.001)。结果显示,低白蛋白血症与SAH患者的预后不良相关。