硫糖铝联合给药期间西咪替丁在人体中的吸收情况。
Cimetidine absorption in humans during sucralfate coadministration.
作者信息
D'Angio R, Mayersohn M, Conrad K A, Bliss M
出版信息
Br J Clin Pharmacol. 1986 May;21(5):515-20. doi: 10.1111/j.1365-2125.1986.tb02834.x.
Abstract
Cimetidine absorption after a single 300 mg oral dose was evaluated in six normal subjects in the absence or presence of sucralfate. Sucralfate was ingested four times a day for 2 days prior to and for two additional doses on the day of cimetidine ingestion. Sucralfate coadministration had no statistically significant influence on the rate or extent of cimetidine absorption.
摘要
在六名正常受试者中，评估了在不存在或存在硫糖铝的情况下，单次口服300毫克西咪替丁后的吸收情况。在摄入西咪替丁之前的2天以及摄入西咪替丁当天额外的两剂期间，硫糖铝每天服用四次，共服用2天。联合使用硫糖铝对西咪替丁的吸收速率或吸收程度没有统计学上的显著影响。
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本文引用的文献
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