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比较不同级别胶质瘤中经典和非经典炎性小体的表达：评估它们作为侵袭性标志物的潜力。

Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker.

作者信息

Kim Yu Jin, Choi Wooseok, Sim JeongMin, Ahn Ju Won, Park JeongMan, Kim Dongkil, Jeong Ju-Yeon, Lee Ji Min, Cho Kyunggi, Moon Jong-Seok, Moon Ju Hyung, Sung Kyoung Su, Lim Jaejoon

机构信息

Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.

Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.

出版信息

Brain Tumor Res Treat. 2023 Jul;11(3):191-203. doi: 10.14791/btrt.2023.0008.

DOI:10.14791/btrt.2023.0008
PMID:37550819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10409615/
Abstract

BACKGROUND

Inflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on glioma malignancy.

METHODS

We performed bioinformatics analysis to confirm the expression of canonical and non-canonical inflammasome-related molecules according to the degree of malignancy through immunohistochemical examination of glioma tissues obtained with patient consent from our institution.

RESULTS

Bioinformatics analysis confirmed that the expression levels of non-canonical inflammasome-related molecules were significantly higher in tumor tissues than in normal tissues, and they also increased according to malignancy, which adversely affected the survival rate. Furthermore, in gliomas, positive correlations were found between N-form gasdermin-D, a key molecule associated with the non-canonical inflammasome, and other related molecules, including NLRP3, caspase-1, caspase-4, and caspase-5. These results were verified by immunohistochemical examination of glioma tissues, and the expression levels of these molecules also increased significantly with increasing grade. In addition, the features of pyroptosis were confirmed.

CONCLUSION

This study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.

摘要

背景

炎性小体在炎症反应的启动中起关键作用，有助于机体防御。然而，当免疫系统失衡时，这些复合物会促进肿瘤进展。本研究旨在探讨非经典炎性小体对胶质瘤恶性程度的影响。

方法

我们进行了生物信息学分析，通过对经患者同意从本机构获取的胶质瘤组织进行免疫组化检查，根据恶性程度确认经典和非经典炎性小体相关分子的表达情况。

结果

生物信息学分析证实，非经典炎性小体相关分子在肿瘤组织中的表达水平显著高于正常组织，且随着恶性程度增加而升高，这对生存率产生了不利影响。此外，在胶质瘤中，与非经典炎性小体相关的关键分子N-端gasdermin-D与其他相关分子（包括NLRP3、caspase-1、caspase-4和caspase-5）之间存在正相关。这些结果通过胶质瘤组织的免疫组化检查得到验证，并且这些分子的表达水平也随着分级增加而显著升高。此外，还证实了细胞焦亡的特征。

结论

本研究确定了非经典炎性小体作为胶质瘤侵袭性标志物的潜力，并为改善胶质瘤治疗提供了一个视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/df5ead39be68/btrt-11-191-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/41c6bc1c82b0/btrt-11-191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/a01b59f327d7/btrt-11-191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/c30837c83f64/btrt-11-191-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/3ed2261b6f35/btrt-11-191-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/df5ead39be68/btrt-11-191-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/41c6bc1c82b0/btrt-11-191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/a01b59f327d7/btrt-11-191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/c30837c83f64/btrt-11-191-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/3ed2261b6f35/btrt-11-191-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f6/10409615/df5ead39be68/btrt-11-191-g005.jpg

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本文引用的文献

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Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis.
胶质瘤诊断、治疗及预后中的潜在生物标志物与挑战
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