Department of Life Sciences, Kyonggi University, Suwon 16227, Republic of Korea.
Int J Mol Sci. 2023 Jun 20;24(12):10402. doi: 10.3390/ijms241210402.
Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on inflammatory responses and diseases induced by canonical inflammasomes, an increasing number of studies have demonstrated that non-canonical inflammasomes, such as mouse caspase-11 and human caspase-4 inflammasomes, are emerging key players in inflammatory responses and various diseases. Flavonoids are natural bioactive compounds found in plants, fruits, vegetables, and teas and have pharmacological properties in a wide range of human diseases. Many studies have successfully demonstrated that flavonoids play an anti-inflammatory role and ameliorate many inflammatory diseases by inhibiting canonical inflammasomes. Others have demonstrated the anti-inflammatory roles of flavonoids in inflammatory responses and various diseases, with a new mechanism by which flavonoids inhibit non-canonical inflammasomes. This review discusses recent studies that have investigated the anti-inflammatory roles and pharmacological properties of flavonoids in inflammatory responses and diseases induced by non-canonical inflammasomes and further provides insight into developing flavonoid-based therapeutics as potential nutraceuticals against human inflammatory diseases.
炎症小体是一种多蛋白复合物，通过诱导细胞焦亡和促炎细胞因子的分泌来激活炎症反应。除了先前大量关于经典炎症小体诱导的炎症反应和疾病的研究外，越来越多的研究表明，非经典炎症小体，如鼠 caspase-11 和人 caspase-4 炎症小体，是炎症反应和各种疾病中的新兴关键因素。类黄酮是植物、水果、蔬菜和茶中天然存在的生物活性化合物，具有广泛的人类疾病的药理学特性。许多研究成功地证明了类黄酮通过抑制经典炎症小体发挥抗炎作用，并改善许多炎症性疾病。其他研究表明，类黄酮在炎症反应和各种疾病中的抗炎作用，具有通过抑制非经典炎症小体发挥抗炎作用的新机制。本综述讨论了最近的研究，这些研究调查了类黄酮在非经典炎症小体诱导的炎症反应和疾病中的抗炎作用和药理学特性，并进一步深入了解了开发基于类黄酮的治疗方法作为治疗人类炎症性疾病的潜在营养疗法。
