Vomachka A J, Lisk R D
Horm Behav. 1986 Jun;20(2):181-93. doi: 10.1016/0018-506x(86)90016-4.
Using radioimmunoassay we have measured the plasma and amniotic fluid levels of androgen and estradiol in male and female hamster fetuses nearing parturition. On Days 14 and 15 of gestation (day of birth = Day 16), plasma levels of androgen are higher in males than females while estradiol levels are equal. Amniotic fluid levels of these hormones, while lower than plasma, reflect the difference in androgen and the similarity in estradiol between sexes. Uterine position analysis on Day 14 suggests that female siblings located caudally suppress amniotic fluid androgen and elevate estradiol levels of male siblings. Comparison of Day 18 gestation male and female rat amniotic fluid androgen to Day 14 hamsters reveals that male rats are bathed in high levels of androgen. Female rats have lower levels which are not different from those of male hamsters. Female hamsters are exposed to little androgen. Relevance to behavioral sexual differentiation and the display of adult behavior is discussed.
我们采用放射免疫分析法测定了接近分娩的雄性和雌性仓鼠胎儿的血浆及羊水雄激素和雌二醇水平。在妊娠第14天和第15天（出生日为第16天），雄性胎儿血浆中的雄激素水平高于雌性，而雌二醇水平相等。这些激素的羊水水平虽低于血浆，但反映出两性之间雄激素的差异和雌二醇的相似性。对第14天的子宫位置分析表明，位于尾部的雌性同胞会抑制羊水雄激素水平，并提高雄性同胞的雌二醇水平。将妊娠第18天的雄性和雌性大鼠羊水雄激素水平与第14天的仓鼠进行比较发现，雄性大鼠浸泡在高水平的雄激素中。雌性大鼠的雄激素水平较低，与雄性仓鼠的水平没有差异。雌性仓鼠接触的雄激素很少。文中还讨论了其与行为性分化及成年行为表现的相关性。
