Nagamani M, McDonough P G, Ellegood J O, Mahesh V B
Am J Obstet Gynecol. 1979 Jul 15;134(6):674-80. doi: 10.1016/0002-9378(79)90649-5.
Concentrations of testosterone, dihydrotestosterone, androstenedione, progesterone, 17 alpha-hydroxyprogesterone, and estradiol were measured by radioimmunoassay in the amniotic fluid and maternal peripheral blood obtained from normal pregnancies between 14 and 40 weeks of gestation. There was a sex difference in the levels of all the androgenic steroids in the amniotic fluid before 20 weeks with higher levels in pregnancies with male fetuses. Amniotic fluid 17 alpha-hydroxyprogesterone levels were significantly elevated in a pregnancy with the fetus affected with congenital adrenal hyperplasia. The levels of all the steroids in the amniotic fluid were significantly elevated in the pregnancy with molar degeneration of the placenta. There was a sex difference in the levels of dihydrotestosterone in the maternal peripheral blood before 20 weeks with higher levels in pregnancies with male fetuses. There was no correlation between the steroid levels in the maternal serum and amniotic fluid even though most of the samples of maternal serum were drawn at the same time as amniocentesis.
采用放射免疫分析法测定了妊娠14至40周正常孕妇羊水和母体外周血中睾酮、双氢睾酮、雄烯二酮、孕酮、17α-羟孕酮和雌二醇的浓度。妊娠20周前，羊水中所有雄激素类固醇水平存在性别差异，男性胎儿妊娠时水平较高。先天性肾上腺皮质增生症胎儿的妊娠羊水中17α-羟孕酮水平显著升高。胎盘水泡样变性妊娠时，羊水中所有类固醇水平均显著升高。妊娠20周前，母体外周血中双氢睾酮水平存在性别差异，男性胎儿妊娠时水平较高。尽管大多数母血样本是在羊膜腔穿刺术同时采集的，但母血和羊水中的类固醇水平之间没有相关性。
