Holmes R A, Wilson R C, McCall J W
Int J Biomed Comput. 1986 May;18(3-4):203-12. doi: 10.1016/0020-7101(86)90017-6.
A microcomputer program using an electronic spreadsheet program was developed to calculate pharmacokinetic values of thiacetarsamide sodium, a drug used to kill the adult heartworm (Dirofilaria immitis) parasite of the dog. A least squares, semilogarithmic regression analysis was done on data using a two compartment intravenous model. The data entered includes the time after injection and the drug concentration at that time. A graph of the points can be viewed or plotted, with the time on the x-axis, and the natural log of the drug concentration on the y-axis. The program was developed on a Televideo (512 kbytes) microcomputer. The spreadsheet used was Lotus 123 with the pharmacokinetics program occupying 16 kbytes of memory (720 cells) out of the 400 kbytes available with Lotus.
开发了一个使用电子表格程序的微型计算机程序，用于计算硫胂酸钠的药代动力学值。硫胂酸钠是一种用于杀死犬类成年心丝虫（恶丝虫）寄生虫的药物。使用二室静脉注射模型对数据进行最小二乘半对数回归分析。输入的数据包括注射后的时间以及该时间的药物浓度。可以查看或绘制各点的图表，其中x轴为时间，y轴为药物浓度的自然对数。该程序是在一台Televideo（512千字节）微型计算机上开发的。使用的电子表格是Lotus 123，药代动力学程序占用了Lotus可用的400千字节中的16千字节内存（720个单元格）。
