Ananchaisarp Thareerat, Chamroonkiadtikun Panya, Julamanee Jakrawadee, Perdvong Kewalee, Chimpalee Thitawan, Rattanavirakul Nutnicha, Leelarujijaroen Nattawat, Hathaipitak Tiprada, Tantinam Thanarat
Division of Family and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Asian Biomed (Res Rev News). 2023 Jun 16;16(5):273-282. doi: 10.2478/abm-2022-0030. eCollection 2022 Oct.
Eosinophilia is a common, hematologic abnormality detected in periodic health checkups with diverse etiologies. There are a few clinical practice guidelines for the management of eosinophilia.
To determine the prevalence of eosinophilia among patients undergoing periodic health examinations, evaluate its management and outcomes, and identify its associated factors.
We conducted a retrospective study that included patients with eosinophilia diagnosed during the 2018 periodic health examinations at Songklanagarind Hospital.
The prevalence rate of eosinophilia was 9.6% (988/10,299), and most patients (52.6%) were male with a median age of 53.0 (42.0-61.0) years. Only 174 patients (17.6%) were diagnosed and further examined to identify the cause of eosinophilia; including an examination of medical history (18.4%), physical examination (93.1%), laboratory analysis (9.2%), and consultation with internists (14.9%). Empirical anthelmintic therapy was administered in 130 patients (74.7%), and 49.2% achieved resolution. The possible causes of eosinophilia were identified in 20.7% (204/988), the most common cause being atopic disease (51.5%). Patients with moderate-to-severe eosinophilia were significantly more likely to be diagnosed, undergo further laboratory tests, and proceed with consultations with internists (adjusted OR [95% CI] = 3.52 [1.97-6.32], 17.13 [5.74-51.11], and 6.38 [1.95-20.93], respectively).
Eosinophilia is commonly identified in periodic health examinations, and most primary physicians lack knowledge regarding the diagnostic work-up required to determine the cause of eosinophilia. Empirical anthelmintic therapy showed satisfactory efficacy for the management of eosinophilia in areas where parasite infection is endemic.
嗜酸性粒细胞增多是定期健康检查中常见的血液学异常，病因多样。目前针对嗜酸性粒细胞增多的管理有一些临床实践指南。
确定定期健康检查患者中嗜酸性粒细胞增多的患病率，评估其管理情况和结局，并识别相关因素。
我们进行了一项回顾性研究，纳入了2018年宋卡王子医院定期健康检查期间诊断为嗜酸性粒细胞增多的患者。
嗜酸性粒细胞增多的患病率为9.6%（988/10299），大多数患者（52.6%）为男性，中位年龄为53.0（42.0 - 61.0）岁。只有174例患者（17.6%）被诊断并进一步检查以确定嗜酸性粒细胞增多的原因；包括病史检查（18.4%）、体格检查（93.1%）、实验室分析（9.2%）和咨询内科医生（14.9%）。130例患者（74.7%）接受了经验性驱虫治疗，49.2%的患者症状得到缓解。20.7%（204/988）的患者确定了嗜酸性粒细胞增多的可能原因，最常见的原因是特应性疾病（51.5%）。中重度嗜酸性粒细胞增多的患者被诊断、接受进一步实验室检查和咨询内科医生的可能性显著更高（调整后的OR [95% CI]分别为3.52 [1.97 - 6.32]、17.13 [5.74 - 51.11]和6.38 [1.95 - 20.93]）。
嗜酸性粒细胞增多在定期健康检查中很常见，大多数初级医生缺乏确定嗜酸性粒细胞增多原因所需的诊断检查知识。在寄生虫感染流行地区，经验性驱虫治疗对嗜酸性粒细胞增多的管理显示出令人满意的疗效。
